Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features.

Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features. Research Abstract Details 

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Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features. Abstract Text:

Takatsugu Kawase,Etsuo Kunieda,Hossain M Deloar,Satoshi Seki,Akitomo Sugawara,Takanori Tsunoo,Eileen N Ogawa,Akitoshi Ishizaka,Kaori Kameyama,Atsuya Takeda,Atsushi Kubo,Takatsugu Kawase,Etsuo Kunieda,Hossain M Deloar,Satoshi Seki,Akitomo Sugawara,Takanori Tsunoo,Eileen N Ogawa,Akitoshi Ishizaka,Kaori Kameyama,Atsuya Takeda,Atsushi Kubo,

PURPOSE: The aim of this study was to establish an animal experimental model of pulmonary stereotactic irradiation and clarify the morphological patterns of pulmonary radiation injury with computed tomography and the histopathological features. MATERIALS AND METHODS: Tiny spherical regions in the lungs of seven anesthetized rabbits were irradiated stereotactically with a single fractional dose of 21-60 Gy. Subsequently, the irradiated lungs were observed biweekly with computed tomography (CT) for 24 weeks. Radiation injury of the lung was examined histopathologically in one specimen. RESULTS: Localized hypodense changes were observed 7-15 weeks after irradiation in three rabbits irradiated with 60 Gy, and the findings persisted beyond that time. The electron density ratios in the lung fields obtained from the CT images were shown to be decreasing, corresponding to the hypodensity changes. No clear increased density opacity was observed in any rabbit in the 60-Gy irradiated group. Severe localized fibrotic change was observed in the histopathological specimens. CONCLUSION: Specific localized hypodensity changes were found in only three rabbits irradiated with 60 Gy, the highest dose we employed.

Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features. Publishing Authors By Initials

T Kawase,E Kunieda,HM Deloar,S Seki,A Sugawara,T Tsunoo,EN Ogawa,A Ishizaka,K Kameyama,A Takeda,A Kubo,T Kawase,E Kunieda,HM Deloar,S Seki,A Sugawara,T Tsunoo,EN Ogawa,A Ishizaka,K Kameyama,A Takeda,A Kubo,

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Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Radiation medicine

VOLUME: 25

Page Numbers: 453-61

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ISSN: 0288-2043

DAY: 26

MONTH: 11

YEAR: 2007

Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopathological features.

AFFILIATION: Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Country: Japan

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MEDLINETA: Radiat Med

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