Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements.

Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Research Abstract Details 

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Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Abstract Text:

H S Sandhu,L E Kanim,J M Toth,J M Kabo,D Liu,R B Delamarter,E G Dawson,

STUDY DESIGN: L4-L5 intertransverse process fusions were produced with 58 micrograms, 230 micrograms, or 920 micrograms of recombinant human bone morphogenetic protein-2 in 20 dogs. Eleven had traditional decortication of posterior elements before insertion of the implant. Nine were left undecorticated. All animals were evaluated 3 months after surgery. OBJECTIVES: To determine whether decortication is a prerequisite for successful fusion in the presence of osteoinductive proteins such as bone morphogenetic protein-2. SUMMARY OF BACKGROUND DATA: Recombinant osteoinductive proteins can induce de novo bone in ectopic soft-tissue sites in the absence of bone marrow elements. Traditional methods for achieving spinal fusion rely on exposure of bone marrow through decortication to facilitate osteogenesis. It is hypothesized that the presence of an implanted osteoinductive protein obviates the need for exposure and release of host inductive factors. METHODS: Recombinant human bone morphogenetic protein-2-induced intertransverse process fusions were performed with and without decortication. Fusion sites were evaluated by computed tomography imaging, high-resolution radiography, manual testing, mechanical testing, and histologic analysis. RESULTS: One hundred percent of decorticated spines and 89% of undecorticated spines were clinically fused by 3 months. Ninety-one percent of decorticated spines and 78% of undecorticated specimens exhibited bilateral transverse process osseous bridging. The only spines that failed to achieve solid bilateral arthrodesis were in the lowest dose group. With the higher two doses, there was histologic evidence of osseous continuity between the fusion mass and undecorticated transverse processes. CONCLUSIONS: There were no statistical differences in clinical and radiographic fusion rates between decorticated and undecorticated sites. With higher doses of recombinant human bone morphoganetic protein-2, there was little histologic distinction between fusions in decorticated versus undecorticated spines.

Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Publishing Authors By Initials

HS Sandhu,LE Kanim,JM Toth,JM Kabo,D Liu,RB Delamarter,EG Dawson,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Spine

VOLUME: 22

Page Numbers: 1171-80

Journal Abbreviation: Spine

ISSN: 0362-2436

DAY: 1

MONTH: Jun

YEAR: 1997

Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Information

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LANGUAGE: eng

NlmUniqueID: 7610646

Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Information

Substance Name: recombinant human bone morphogenetic pro

Registry Number: 0

Grant and Affiliation Information for Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements.

AFFILIATION: Department of Orthopaedic Surgery, UCLA School of Medicine, USA.

Country: UNITED STATES

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MEDLINETA: Spine

REFSOURCE: Spine 1997 Oct 15;22(20):2463

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