[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus]

[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus] Research Abstract Details 

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[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus] Abstract Text:

Z J Wang,Z Q Yang,T N Huang,L Wen,Y W Liu,

OBJECTIVE: To investigate the antiviral effect of two components (B and C) in the alcohol extracts from Loranthus yadoriki Sieb for development of new antiviral drugs for coxsackie B3 virus(CVB3). METHOD: Using ribavirin as positive control, the plaque reduction assay was adopted for pharmadynamic detection. RESULTS: In the HEp-2 cell system, with respect to direct virucidal activity and the inhibition on CVB3 infection and multiplication, ED50s of component B were 2.32 micrograms.ml-1, 0.24 microgram.ml-1 and 1.91 micrograms.ml-1, respectively and those of component C, 1.44 micrograms.ml-1, 2.06 micrograms.ml-1 and 3.70 micrograms.ml-1 respectively. For the inhibition on multiplication of CVB3, ED50 of ribavirin was 7.55 micrograms.ml-1. CONCLUSION: Treatment indexes (TI) of the direct virucidal activity and inhibitory effects of component B on CVB3 infection and multiplication 22.6, 219 and 27.5 respectively; component C, 115, 165 and 21.6; inhibition of ribavirin on CVB3 is 38, which is comparable to those of components B and C. It is thus suggested that the anti-CVB3 action of components B and C in the alcohol extracts from Loranthus yadoriki Sieb deserves to be exploited.

[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus] Publishing Authors By Initials

ZJ Wang,ZQ Yang,TN Huang,L Wen,YW Liu,

For similar plants: plants, medicinal research abstracts see: plants: plants, medicinal research

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[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazh

VOLUME: 25

Page Numbers: 685-7

Journal Abbreviation: Zhongguo Zhong Yao Za Zhi

ISSN: 1001-5302

DAY: 6

MONTH: Nov

YEAR: 2000

[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus] Information

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LANGUAGE: chi

NlmUniqueID: 8913656

[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus] Keywords Mesh Terms:

KEYWORDS: Plants, Medicinal

MESH TERMS: chemistry

Chemical & Substance for Abstract: [Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus] Information

Substance Name: Drugs, Chinese Herbal

Registry Number: 0

Grant and Affiliation Information for [Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus]

AFFILIATION: Virus Research Institute, Hubei Medical University, Wuhan 430071, Hubei, China.

Country: China

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MEDLINETA: Zhongguo Zhong Yao Za Zhi

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