[Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice]

[Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice] Research Abstract Details 

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[Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice] Abstract Text:

Yun-hui Shen,Chang-xun Chen,Zhen-ye Xu,

OBJECTIVE: To investigate the leukogenic function of Shuanghuang Shengbai (SHSB) granule and the related mechanisms. METHOD: Mouse leukopenic models were induced by radiation. Mice were divided into normal control group, model control group, positive control group-Li kejun tablet group and three different dose (high, middle, low-dose) groups of SHSB granule. The peripheral hemogram, thymus index (TI), spleen index (SI), bone marrow nucleated cell (BMNC) and colony forming unit-spleen (CFU-S) were evaluated. The proliferation of bone marrow cells was determined. The in vitro cultured colony forming unit granulocyte macrophage (CFU-GM) was estimated. The index of CD34+ cell in BMNC were determined by flow cytometry. The ultra-micro structure of bone marrow were observed by electromicroscope. RESULT: (1)SHSB rranule could increase the WBC of model mice; (2)SHSB granule could increase BMNC and promote the proliferation of bone marrow cell; (3)SHSB granule could increase CFU-S, CFU-GM and CD34+ cell index in BMNC of model mice significantly; (4)SHSB Granule could also protect the bone marrow hemotopoietic microenvironment from the harm of radiation; (5)SHSB granule could increase the SI of model mice, indicating the enhancement of immunological function. CONCLUSION: SHSB granule has apparent leukogenic function. The mechanism may be related to enhancing the proliferation of hematopoietic cells and protecting the bone marrow hemotopoietic microenvironment.

[Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice] Publishing Authors By Initials

YH Shen,CX Chen,ZY Xu,

For similar plants: plants, medicinal research abstracts see: plants: plants, medicinal research

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[Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazh

VOLUME: 31

Page Numbers: 754-9

Journal Abbreviation: Zhongguo Zhong Yao Za Zhi

ISSN: 1001-5302

DAY: 6

MONTH: May

YEAR: 2006

[Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice] Information

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LANGUAGE: chi

NlmUniqueID: 8913656

[Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice] Keywords Mesh Terms:

KEYWORDS: Plants, Medicinal

MESH TERMS: chemistry

Chemical & Substance for Abstract: [Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice] Information

Substance Name: Drugs, Chinese Herbal

Registry Number: 0

Grant and Affiliation Information for [Experimental research of Shuanghuang Shengbai granule on hematopoietic cells of leucopenia model mice]

AFFILIATION: Department of Pharmacology, Shanghai University of Traditional Chinese Medicine.

Country: China

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MEDLINETA: Zhongguo Zhong Yao Za Zhi

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