Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine.

Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine. Research Abstract Details 

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Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine. Abstract Text:

N Schwarz,H Redl,G Schlag,F Lintner,H P Dinges,M Thurnher,A Schiesser,

An experimental study in rats was done to investigate the bone-regenerating properties of collagen apatite (Collapat) and to compare it with osteoinduction dependent on osteogenin-containing gelatine (OCG). The test substances were implanted orthotopically (calvarial defect--7 mm in diameter) and heterotopically (paravertebral muscles, abdominal muscles). The results were evaluated histologically and enzymatically (alkaline phosphatase). Collapat caused neither osteoinduction in the heterotopic site nor healing of the bone defects. Foreign body reaction without new bone formation was encountered. OCG implantation leads to new bone formation in the muscles within 3 weeks, associated with a significant increase in alkaline phosphatase activity, and to extensive new bone formation in the calvarial defect within 4 weeks. The defects did not heal if left empty. The value of clinical application of Collapat appears to be doubtful. Osteoinduction with OCG requires further experimental investigation.

Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine. Publishing Authors By Initials

N Schwarz,H Redl,G Schlag,F Lintner,HP Dinges,M Thurnher,A Schiesser,

For similar complex mixtures: tissue extracts research abstracts see: complex mixtures: tissue extracts research

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Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of orthopaedic and traumatic surgery. Arc

VOLUME: 106

Page Numbers: 113-9

Journal Abbreviation:

ISSN: 0344-8444

DAY: 21

MONTH: 02

YEAR: 1987

Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine. Information

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LANGUAGE: eng

NlmUniqueID: 7803037

Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine. Keywords Mesh Terms:

KEYWORDS: Tissue Extracts

MESH TERMS: pathology

Chemical & Substance for Abstract: Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Experimental osteoinduction in rats: collagen-apatite versus osteogenin-containing gelatine.

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Country: GERMANY, WEST

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MEDLINETA: Arch Orthop Trauma Surg

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