Experimental model for the study of chronic renal ischemia in rats: morphologic, histological and ultra-structural analysis.

Experimental model for the study of chronic renal ischemia in rats: morphologic, histological and ultra-structural analysis. Research Abstract Details 

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Experimental model for the study of chronic renal ischemia in rats: morphologic, histological and ultra-structural analysis. Abstract Text:

Konopka,Alexandre Jurach,Orlando Carlos Belmonte Wender,

PURPOSE: To evaluate a model of chronic renal ischemia in rats and to characterize the effects on renal tissue. METHODS: 168 Wistar rats were divided into two equal groups, control (GC) and ischemia (GI). The animals of the GI (n=84) were submitted to partial ligation of the left renal artery, and the animals of GC (n=84) stayed with the renal artery intact. In seven successive and identical periods of time, in weekly intervals, 12 animals of each group were submitted to nephrectomy, with morphometric determinations and histological and ultra-structural analysis. RESULTS: The GI presented progressive reduction in renal weight, volume and cortical thickness observed from the 7th day of the experiment, reaching maximum degree in the 49th day (p < 0.05). The proximal tubular atrophy in the GI was observed in 75/84 analysis (89,2%), with highly significant difference among the groups starting from the 7th day (p=0 .0009) and in the other periods of the experiment (p=0 .00001). The most prevalent interstitial alteration was the infiltrate, present in 98,8% of the GI, with highly significant difference among the groups in the whole experiment (p=0 .00001). Ultra-structural analysis didn't demonstrate glomerular lesions, evidencing that the glomerule preserves its intact architecture during chronic ischemia. CONCLUSION: The model showed that chronic renal ischemia in rats provokes progressive renal atrophy, with preservation of glomerular structure.

Experimental model for the study of chronic renal ischemia in rats: morphologic, histological and ultra-structural analysis. Publishing Authors By Initials

CL Konopka,A Jurach,OC Wender,

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Experimental model for the study of chronic renal ischemia in rats: morphologic, histological and ultra-structural analysis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta cirúrgica brasileira / Sociedade Brasileira p

VOLUME: 22

Page Numbers: 12-21

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ISSN: 0102-8650

DAY: 12

MONTH: 02

YEAR: 2007

Experimental model for the study of chronic renal ischemia in rats: morphologic, histological and ultra-structural analysis. Information

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LANGUAGE: eng

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AFFILIATION: Department of Surgery, Federal University of Santa Maria, 97015-190 Santa Maria, Rio Grande do Sul, Brazil. konopka@terra.com.br

Country: Brazil

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MEDLINETA: Acta Cir Bras

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