Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication.

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. Research Abstract Details 

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Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. Abstract Text:

Diane M Janowicz,Klara Tenner-Racz,Paul Racz,Tricia L Humphreys,Carol Schnizlein-Bick,Kate R Fortney,Beth Zwickl,Barry P Katz,James J Campbell,David D Ho,Stanley M Spinola,

We infected 11 HIV-seropositive volunteers whose CD4(+) cell counts were >350 cells/ microL (7 of whom were receiving antiretrovirals) with Haemophilus ducreyi. The papule and pustule formation rates were similar to those observed in HIV-seronegative historical control subjects. No subject experienced a sustained change in CD4(+) cell count or HIV RNA level. The cellular infiltrate in biopsy samples obtained from the HIV-seropositive and HIV-seronegative subjects did not differ with respect to the percentage of leukocytes, neutrophils, macrophages, or T cells. The CD4(+):CD8(+) cell ratio in biopsy samples from the HIV-seropositive subjects was 1:3, the inverse of the ratio seen in the HIV-seronegative subjects (P<.0001). Although CD4(+) cells proliferated in lesions, in situ hybridization and reverse-transcription polymerase chain reaction for HIV RNA was negative. We conclude that experimental infection in HIV-seropositive persons is clinically similar to infection in HIV-seronegative persons and does not cause local or augment systemic viral replication. Thus, prompt treatment of chancroid may abrogate increases in viral replication associated with natural disease.

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. Publishing Authors By Initials

DM Janowicz,K Tenner-Racz,P Racz,TL Humphreys,C Schnizlein-Bick,KR Fortney,B Zwickl,BP Katz,JJ Campbell,DD Ho,SM Spinola,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 195

Page Numbers: 1443-51

Journal Abbreviation:

ISSN: 0022-1899

DAY: 5

MONTH: 04

YEAR: 2007

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: blood

Chemical & Substance for Abstract: Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. Information

Substance Name: RNA, Viral

Registry Number: 0

Grant and Affiliation Information for Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication.

AFFILIATION: Department of Medicine, Indiana University, School of Medicine, Indianapolis, IN 46202, USA. dmjanowi@iupui.edu

Country: United States

AGENCY: United States NIAID

GRANT: T32 AI007637

ACRONYM: AI

MEDLINETA: J Infect Dis

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• Identification of Haemophilus ducreyi genes expressed during human infection.
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