Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases.

Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. Research Abstract Details 

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Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. Abstract Text:

W T Yuh,J D Engelken,M G Muhonen,N A Mayr,D J Fisher,J C Ehrhardt,

PURPOSE: To assess the effectiveness and safety of higher doses of gadoteridol in the MR evaluation of patients with brain metastases. MATERIALS AND METHODS: Thirty-one patients with a clinical suspicion of brain metastases were studied prospectively with gadoteridol, a new, nonionic, low-osmolality contrast agent. Each patient received an initial injection of 0.1 mmol/kg and an additional dose of 0.2 mmol/kg 30 minutes later. Images were obtained before, immediately after, and 10 and 20 minutes after the initial dose. Images also were acquired immediately after the additional dose of gadoteridol. RESULTS: No adverse effects were attributed to the injection of gadoteridol. Four patients' examinations were excluded from analysis because of machine malfunction (two patients) and excessive motion artifact (two patients). Four patients had no detectable metastases. After the additional dose of gadoteridol, there was a marked qualitative improvement in lesion conspicuity and detection. The conspicuity of 80 of 81 lesions was increased in the high-dose studies, and 46 new lesions were detected in 19 of 27 patients. Quantitative image analysis demonstrated a significant increase in normalized mean lesion contrast between the initial-dose and high-dose studies (35 lesions identified in 13 patients, P less than .0001). The additional information gained by high-dose examinations contributed to a potential modification of the treatment in 10 of 27 patients. High-dose examinations increased flow-related artifact in the posterior fossa in 12 of 27 patients. CONCLUSION: Based on our preliminary results, high-dose gadolinium-enhanced MR examinations may have advantages over 0.1 mmol/kg examinations in detecting early and/or small metastases. This may be significant in the management of patients with cerebral metastases.

Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. Publishing Authors By Initials

WT Yuh,JD Engelken,MG Muhonen,NA Mayr,DJ Fisher,JC Ehrhardt,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

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Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJNR. American journal of neuroradiology

VOLUME: 13

Page Numbers: 335-45

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: 02

YEAR: 2008

Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases. Information

Substance Name: Gadolinium

Registry Number: 7440-54-2

Grant and Affiliation Information for Experience with high-dose gadolinium MR imaging in the evaluation of brain metastases.

AFFILIATION: Department of Radiology, University of Iowa College of Medicine, Iowa City, IA 52242.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

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