Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia.

Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. Abstract Text:

C Ertmer,A Morelli,S Rehberg,M Lange,C Hucklenbruch,H Van Aken,M Booke,M Westphal,C Ertmer,A Morelli,S Rehberg,M Lange,C Hucklenbruch,H Van Aken,M Booke,M Westphal,

BACKGROUND: Hypodynamic septic shock is associated with a poor prognosis. The present randomized-controlled laboratory experiment was designed to test the hypothesis that the vasodilatory peptide hormone adrenomedullin (ADM) is a useful agent to prevent and reverse the development of hypodynamic circulation in ovine endotoxaemia. METHODS: Twenty-four healthy ewes were chronically instrumented for haemodynamic monitoring and randomly allocated to either the control, treatment, or prophylaxis group (n = 8 each). After a baseline (BL) measurement in the healthy state, all sheep were subjected to a continuous endotoxin infusion started at 10 ng kg(-1) min(-1) and doubled every hour six times. After 4 h of endotoxin challenge, the treatment group received ADM (50 ng kg(-1) min(-1)) for the remaining 3 h of the experiment. The prophylaxis group received a simultaneous infusion of endotoxin and ADM (50 ng kg(-1) min(-1)) from the beginning to the end of the 7 h intervention period. RESULTS: In the control and treatment groups, the ewes exhibited a hypodynamic circulation at 4 h (>20% reduction in cardiac index, both P < 0.01 vs BL). Endotoxin also increased mean pulmonary arterial pressure (MPAP) and arterial lactate concentrations. Prophylactic infusion of ADM prevented the occurrence of pulmonary hypertension and hypodynamic circulation and thereby blunted the increase in arterial lactate concentrations. In the treatment group, ADM administration increased CI (P < 0.001) and reduced both MPAP (P = 0.023) and arterial lactate concentrations (P < 0.001 each at 7 h) when compared with the control group. CONCLUSIONS: This study demonstrates that exogenous ADM prevents and reverses hypodynamic circulation, attenuates pulmonary hypertension, and limits lactic acidosis in ovine endotoxaemia.

Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. Publishing Authors By Initials

C Ertmer,A Morelli,S Rehberg,M Lange,C Hucklenbruch,H Van Aken,M Booke,M Westphal,C Ertmer,A Morelli,S Rehberg,M Lange,C Hucklenbruch,H Van Aken,M Booke,M Westphal,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of anaesthesia

VOLUME: 99

Page Numbers: 830-6

Journal Abbreviation:

ISSN: 1471-6771

DAY: 25

MONTH: 10

YEAR: 2007

Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372541

Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia.

AFFILIATION: Department of Anaesthesiology and Intensive Care, University Hospital of Muenster, Albert-Schweitzer-Str. 33, D-48149 Muenster, Germany. ertmerc@gmx.net

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Br J Anaesth

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia Related Publications

• Amebiasis with pulmonary involvement.
• Continuous terlipressin infusion in patients with septic shock: less may be best, and the earlier the better?
• Cyclooxygenase-2 inhibition and increased arterial vasoconstriction to vasopressin: What is the link?
• Epidemiology of Epidemic Keratoconjunctivitis.
• Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia.
• Experiences of Somatonorm in Sweden.
• Fleet leaders' attitudes about subordinates' use of mental health services.
• Hemodynamic effects of thoracic epidural analgesia in ovine hyperdynamic endotoxemia.
• Hollow mandrin facilitates external ventricular drainage placement.
• Is short stature a psychosocial handicap?
• LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.
• Living at risk: concealing risk and preserving hope in huntington disease.
• New frontiers in health education.
• Optimal perfusion of an intact ovary as a prerequisite for successful ovarian cryopreservation.
• Preparation and characteristics of corticosteroid-binding globulin (CBG, transcortin).
• Pulmonary resection for metastatic sarcoma.
• Purification of Coxiella burnetii antigen by gel-chromatography for use in enzyme-linked immunosorbent assay (ELISA).
• Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications.
• Sensors, medical image and signal processing. Findings from the section on sensor, signal and imaging informatics.
• Ten years of vasopressin research in septic shock: constant dripping wears the stone.
• The Problem of the Gonococcus Carrier.
• [Immunochemistry of O-antigens of Enterobacteriaceae. IV. Analysis of the sugar constituents of Escherichia O-antigens.]
• [Methods for analysis of amniotic fluid for diagnosis of the fetal condition in Rh-incompatibility]
• [Not Available.]
• [Not Available.]
• [On the immunochemistry of the O-antigen of Enterobacteriaceae. VI. Comparison of the sugar components of polysaccharides from S and R forms of Salmonella.]
• [Perinatal and neonatal mortality and morbidity in newborn infants up to 1,000 g]
• [Reliability and responsiveness of the German version of the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH).]
• [Salivary secretion and gingival hyperplasia in diphenyl hydantoin-treated guinea pigs]
• [Specificity of calcium determination using tetracycline]