[Exhaled nitric oxide in children: a noninvasive marker of airway inflammation]

[Exhaled nitric oxide in children: a noninvasive marker of airway inflammation] Research Abstract Details 

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[Exhaled nitric oxide in children: a noninvasive marker of airway inflammation] Abstract Text:

Cobos Barroso,Eduardo G ,Olaia ,Conrado ,Silvia Gartner,Javier Korta Murua,

This article is an academic review of the application in children of the measurement of fractional exhaled nitric oxide (FENO). We outline the joint American Thoracic Society/European Respiratory Society recommendations for online measurement of FENO in both cooperating children and children unable to cooperate, offline measurement with uncontrolled exhalation flow rate, offline measurement with controlled exhalation flow rate using a dynamic flow restrictor, and offline measurement during tidal breathing in children unable to cooperate. This is followed by a review of the normal range of values for single-breath online measurements obtained with a chemiluminescence FENO analyzer (geometric mean, 9.7 parts per billion [ppb]; upper limit of the 95% confidence interval, 25.2 ppb). FENO values above 17 ppb have a sensitivity of 81% and a specificity of 80% for predicting asthma of an eosinophilic phenotype. We discuss the response of FENO values to anti-inflammatory treatment and the use of this marker in the management of asthma. Results obtained with chemiluminescence and portable electrochemical analyzers are compared. The portable devices offer the possibility--in children over 5 years of age--of accurate and universal monitoring of exhaled nitric oxide concentrations, an emerging marker of eosinophilic inflammation in asthma that facilitates diagnosis, monitoring of disease progression, and assessment of response to therapy.

[Exhaled nitric oxide in children: a noninvasive marker of airway inflammation] Publishing Authors By Initials

N Cobos Barroso,EG ,O ,C ,S Gartner,J Korta Murua,

For similar respiratory tract diseases: respiration disorders research abstracts see: respiratory tract diseases: respiration disorders research

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[Exhaled nitric oxide in children: a noninvasive marker of airway inflammation] Journal Published:

PUBLICATION TYPE: Review

Journal: Archivos de bronconeumología

VOLUME: 44

Page Numbers: 41-51

Journal Abbreviation: Arch. Bronconeumol.

ISSN: 0300-2896

DAY: 29

MONTH: Jan

YEAR: 2008

[Exhaled nitric oxide in children: a noninvasive marker of airway inflammation] Information

Number of References: 79

LANGUAGE: spa

NlmUniqueID: 354720

[Exhaled nitric oxide in children: a noninvasive marker of airway inflammation] Keywords Mesh Terms:

KEYWORDS: Respiration Disorders

MESH TERMS: diagnosis

Chemical & Substance for Abstract: [Exhaled nitric oxide in children: a noninvasive marker of airway inflammation] Information

Substance Name: Nitric Oxide

Registry Number: 10102-43-9

Grant and Affiliation Information for [Exhaled nitric oxide in children: a noninvasive marker of airway inflammation]

AFFILIATION: Unidad de Neumología Pediátrica y Fibrosis Quística, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

Country: Spain

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MEDLINETA: Arch Bronconeumol

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