Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy.

Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy. Research Abstract Details 

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Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy. Abstract Text:

K W Tsang,K C Tan,P L Ho,G C Ooi,P L Khong,R Leung,J C Mak,G L Tipoe,C Ko,W K Lam,

SETTING: While exhaled nitric oxide (eNO) levels are reduced by inhaled corticosteroid therapy in asthma, such treatment effect is unclear in bronchiectasis. DESIGN: Stable non-smoking bronchiectasis patients were randomised to receive either fluticasone (1 mg/daily) or identical placebo via the Accuhaler device. RESULTS: Sixty non-smoking patients (38 women; mean age 56.4 +/- 12.7 years) were recruited. Of these, half received inhaled fluticasone and half placebo therapy. eNO was measured using a chemiluminescence analyser at 0, 4, 12, 24, 36 and 52 weeks. There was no significant difference in eNO levels between fluticasone and placebo patients over the study period. There was no correlation between baseline eNO with age, FEV1, FVC, 24 h sputum volume or number of bronchiectatic segments. Patients with Pseudomonas aeruginosa (PA) infection, but not their counterparts, displayed a correlation between 0- and 52-week eNO levels. PA infection was associated with significantly lower eNO levels among the patients. CONCLUSIONS: Inhaled fluticasone therapy, despite being an effective anti-inflammatory agent, has no significant effect on eNO production, either at individual time points or over the entire 52-week profile, in bronchiectasis. It appears that eNO might not reflect the extent of airway inflammation in bronchiectasis.

Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy. Publishing Authors By Initials

KW Tsang,KC Tan,PL Ho,GC Ooi,PL Khong,R Leung,JC Mak,GL Tipoe,C Ko,WK Lam,

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Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The international journal of tuberculosis and lung

VOLUME: 8

Page Numbers: 1301-7

Journal Abbreviation: Int. J. Tuberc. Lung Dis.

ISSN: 1027-3719

DAY: 7

MONTH: Nov

YEAR: 2004

Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy. Information

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LANGUAGE: eng

NlmUniqueID: 9706389

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AFFILIATION: University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China. kwttsang@hku.hk

Country: France

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MEDLINETA: Int J Tuberc Lung Dis

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