Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry.

Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Research Abstract Details 

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Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Abstract Text:

Hye-Won Shin,Christina D Schwindt,Anna S Aledia,Christine M Rose-Gottron,Jennifer K Larson,Robert L Newcomb,Dan M Cooper,Steven C George,

Exhaled nitric oxide (NO) is altered in asthmatic subjects with exercise-induced bronchoconstriction (EIB). However, the physiological interpretation of exhaled NO is limited because of its dependence on exhalation flow and the inability to distinguish completely proximal (large airway) from peripheral (small airway and alveolar) contributions. We estimated flow-independent NO exchange parameters that partition exhaled NO into proximal and peripheral contributions at baseline, postexercise challenge, and postbronchodilator administration in steroid-naive mild-intermittent asthmatic subjects with EIB (24-43 yr old, n = 9) and healthy controls (20-31 yr old, n = 9). The mean +/- SD maximum airway wall flux and airway diffusing capacity were elevated and forced expiratory flow, midexpiratory phase (FEF(25-75)), forced expiratory volume in 1 s (FEV(1)), and FEV(1)/forced vital capacity (FVC) were reduced at baseline in subjects with EIB compared with healthy controls, whereas the steady-state alveolar concentration of NO and FVC were not different. Compared with the response of healthy controls, exercise challenge significantly reduced FEV(1) (-23 +/- 15%), FEF(25-75) (-37 +/- 18%), FVC (-12 +/- 12%), FEV(1)/FVC (-13 +/- 8%), and maximum airway wall flux (-35 +/- 11%) relative to baseline in subjects with EIB, whereas bronchodilator administration only increased FEV(1) (+20 +/- 21%), FEF(25-75) (+56 +/- 41%), and FEV(1)/FVC (+13 +/- 9%). We conclude that mild-intermittent steroid-naive asthmatic subjects with EIB have altered airway NO exchange dynamics at baseline and after exercise challenge but that these changes occur by distinct mechanisms and are not correlated with alterations in spirometry.

Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Publishing Authors By Initials

HW Shin,CD Schwindt,AS Aledia,CM Rose-Gottron,JK Larson,RL Newcomb,DM Cooper,SC George,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, respiratory system: respiratory function tests: spirometry research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, respiratory system: respiratory function tests: spirometry research

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Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Regulatory, integr

VOLUME: 291

Page Numbers: R1741-8

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 13

MONTH: 07

YEAR: 2006

Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Keywords Mesh Terms:

KEYWORDS: Spirometry

MESH TERMS: methods

Chemical & Substance for Abstract: Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Information

Substance Name: Nitric Oxide

Registry Number: 10102-43-9

Grant and Affiliation Information for Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry.

AFFILIATION: Department of Biomedical Engineering, Division of Pulmonary and Critical Care, 3120 Natural Sciences II, University of California-Irvine, Irvine, CA 92697-2715, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR 00827

ACRONYM: RR

MEDLINETA: Am J Physiol Regul Integr Comp

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