Exercise builds brain health: key roles of growth factor cascades and inflammation.

Exercise builds brain health: key roles of growth factor cascades and inflammation. Research Abstract Details 

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Exercise builds brain health: key roles of growth factor cascades and inflammation. Abstract Text:

Carl W Cotman,Nicole C Berchtold,Lori-Ann Christie,

Human and other animal studies demonstrate that exercise targets many aspects of brain function and has broad effects on overall brain health. The benefits of exercise have been best defined for learning and memory, protection from neurodegeneration and alleviation of depression, particularly in elderly populations. Exercise increases synaptic plasticity by directly affecting synaptic structure and potentiating synaptic strength, and by strengthening the underlying systems that support plasticity including neurogenesis, metabolism and vascular function. Such exercise-induced structural and functional change has been documented in various brain regions but has been best-studied in the hippocampus - the focus of this review. A key mechanism mediating these broad benefits of exercise on the brain is induction of central and peripheral growth factors and growth factor cascades, which instruct downstream structural and functional change. In addition, exercise reduces peripheral risk factors such as diabetes, hypertension and cardiovascular disease, which converge to cause brain dysfunction and neurodegeneration. A common mechanism underlying the central and peripheral effects of exercise might be related to inflammation, which can impair growth factor signaling both systemically and in the brain. Thus, through regulation of growth factors and reduction of peripheral and central risk factors, exercise ensures successful brain function.

Exercise builds brain health: key roles of growth factor cascades and inflammation. Publishing Authors By Initials

CW Cotman,NC Berchtold,LA Christie,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

PUBMED ID PMID:

MEDLINE DATE:

Exercise builds brain health: key roles of growth factor cascades and inflammation. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in neurosciences

VOLUME: 30

Page Numbers: 464-72

Journal Abbreviation: Trends Neurosci.

ISSN: 0166-2236

DAY: 31

MONTH: 08

YEAR: 2007

Exercise builds brain health: key roles of growth factor cascades and inflammation. Information

Number of References: 92

LANGUAGE: eng

NlmUniqueID: 7808616

Exercise builds brain health: key roles of growth factor cascades and inflammation. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Exercise builds brain health: key roles of growth factor cascades and inflammation. Information

Substance Name: Nerve Growth Factors

Registry Number: 0

Grant and Affiliation Information for Exercise builds brain health: key roles of growth factor cascades and inflammation.

AFFILIATION: University of California, Irvine Institute for Brain Aging and Dementia, 1113 Gillespie Building, Irvine, CA 92617-4540, USA. cwcotman@uci.edu

Country: England

AGENCY: United States NIA

GRANT: AG00538

ACRONYM: AG

MEDLINETA: Trends Neurosci

REFSOURCE: Trends Neurosci. 2007 Oct;30(10):489

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