Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid.

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Abstract Text:

M P Brown,T N Trumble,A H K Plaas,J D Sandy,M Romano,J Hernandez,K A Merritt,M P Brown,T N Trumble,A H K Plaas,J D Sandy,M Romano,J Hernandez,K A Merritt,

OBJECTIVES: (1) To investigate the effects of exercise and osteochondral (OC) injury on synovial fluid (SF) chondroitin sulfate (CS) and hyaluronan (HA) concentration and chain length, (2) to compare SF and cartilage CS data from joints with OC fragmentation, and (3) to compare SF CS and HA profiles with those seen in serum from the same horses. METHODS: Serum and SF were obtained from (1) normal horses after 8 weeks rest, (2) the same horses after 9 months treadmill training, and (3) horses with OC injury from racing. Articular cartilage was also collected from group 3 horses. Concentrations and chain lengths of CS and HA were determined by gel chromatography and fluorophore-assisted carbohydrate electrophoresis. RESULTS: SF CS peak chain length in the OC injury group increased significantly (18.7kDa) when compared to rested horses (11.6kDa), with exercise producing an intermediate chain length (15.6kDa). Cartilage and serum from the OC injury group had the abnormally long CS chains seen in SF from these horses. Total SF HA was significantly lower in the OC injury group compared to the rested group. Both the OC injury group and the exercised group had significant decreases in SF HA chain length compared to the rested group. CONCLUSIONS: Chain length of SF CS was increased by exercise and OC injury. Exercise resulted in a modest increase, whereas OC injury caused a marked increase. In contrast to CS, SF HA chain length was decreased by OC injury, and to a lesser extent by exercise. Chain length analysis of SF CS and HA may provide a useful tool for evaluation of joint health.

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Publishing Authors By Initials

MP Brown,TN Trumble,AH Plaas,JD Sandy,M Romano,J Hernandez,KA Merritt,MP Brown,TN Trumble,AH Plaas,JD Sandy,M Romano,J Hernandez,KA Merritt,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Osteoarthritis and cartilage / OARS, Osteoarthriti

VOLUME: 15

Page Numbers: 1318-25

Journal Abbreviation:

ISSN: 1063-4584

DAY: 31

MONTH: 05

YEAR: 2007

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9305697

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid.

AFFILIATION: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-1432, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Osteoarthritis Cartilage

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid Related Publications

• A simplified method of determining synovial fluid chondroitin sulfate chain length.
• Advantages of real-time spatial compound sonography of the musculoskeletal system versus conventional sonography.
• Amebiasis; electrocardiographic changes in patients treated with emetine hydrochloride.
• Caramiphen hydrochloride in the treatment of diseases of the basal ganglions.
• Centennial sounding board. Sonography: unlikely success, uncertain future.
• Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
• Commentary: Case reports: an important contribution to chiropractic literature.
• Comparison of radiolytic compounds from saturated and unsaturated triglycerides and fatty acids.
• Confirmatory factor structure of the Center for Epidemiologic Studies-Depression scale (CES-D) in mild-to-moderate traumatic brain injury.
• Digestive enzyme concentrations and activities in healthy pancreatic tissue of horses.
• Dorsal longitudinal stretch receptor of Drosophila melanogaster larva - Fine structure and maturation.
• Effect of smallpox vaccination on the outcome of pregnancy.
• Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid.
• Formation of gamma and delta lactones in irradiated beef.
• Genital trauma in children and adolescents.
• Global health research and professional ethics: ancillary care for research participants.
• Laboratory and clinical experiences with antibiotic and anti-inflammatory agents.
• Maximum gravitational recoil.
• Neurology.
• Osteogenesis imperfecta in the neonate.
• Presacral enterogenous cyst.
• Pulmonary lymphatic air: locating "pulmonary interstitial emphysema" of the premature infant.
• Role of cholecystokinin in the gastric motor response to a meal in horses.
• Synthetic vs human surfactants in the treatment of respiratory distress syndrome: radiographic findings.
• The gym ball as a chair for the back pain patient: A two case report.
• The surgical management of duodenal ulcer.
• The ultrastructure and function of the silk-producing basitarsus in the Hilarini (Diptera: Empididae).
• The use of antiepileptic drugs.
• [Not Available.]
• [Not Available.]