Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats.

Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats. Research Abstract Details 

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Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats. Abstract Text:

Sunmin Park,Sang Mee Hong,So Ra Sung,

Not only exendin-4 but also exercise has been reported to improve glucose homeostasis by enhancing insulinotropic action, but the nature of its molecular mechanism has not been clarified. We investigated a mechanism to promote insulinotropic action by means of exendin-4 and exercise training in 90% pancreatectomized (Px) rats fed 40% energy fat diets. Px diabetic rats were divided into 4 groups: 1) exendin-4, 2) exendin-4 plus exercise, 3) saline (control), and 4) exercise. During the 8-week experimental period, rats in the exendin-4 groups were subcutaneously administered with 150 pmol/kg exendin-4 twice a day, while those in the exercise groups ran on an uphill treadmill with a 15 degree incline at 20 m/min for 30 min 5 days a week. First phase insulin secretion was elevated by both the administration of exendin-4 and exercise training during hyperglycemic clamp. However, second phase insulin secretion did not differ among the groups. Individual treatment of exendin-4 and exercise expanded beta-cell mass by increasing its proliferation and reducing its apoptosis, but the administration of exendin-4 plus exercise training did not produce any additional, positive effects. Both exendin-4 and exercise enhanced insulin receptor substrate (IRS)-2 expression through the activation of cAMP responding element binding protein in the islets, which potentiated their insulin/insulin like growth factor-1 signaling. The potentiation of the signaling increased the expression of pancreas duodenum homeobox-1, involved in beta-cell proliferation. In conclusion, exendin-4 and exercise equivalently improved glucose homeostasis due to the induction of IRS-2 in the islets of diabetic rats through a cAMP dependent common pathway.

Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats. Publishing Authors By Initials

S Park,SM Hong,SR Sung,

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Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Life sciences

VOLUME: 82

Page Numbers: 503-11

Journal Abbreviation: Life Sci.

ISSN: 0024-3205

DAY: 31

MONTH: 12

YEAR: 2007

Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats.

AFFILIATION: Department of Food & Nutrition, College of Natural Science, Hoseo University, Asan-Si, South Korea.

Country: England

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MEDLINETA: Life Sci

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