[Excitotoxic effects of glutamate on the in vitro spiral ganglion cells]

[Excitotoxic effects of glutamate on the in vitro spiral ganglion cells] Research Abstract Details 

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[Excitotoxic effects of glutamate on the in vitro spiral ganglion cells] Abstract Text:

Kaisheng Yan,Qiuhong Xue,Linghui Luo,Shusheng Gong,

OBJECTIVE: To explore the excitotoxic effects of glutamate on the in vitro primarily cultured spiral ganglion cell (SGC) of rat. METHOD: Spiral ganglion cells (SGCs) were cultured in vitro for 4 days, and exposed to 1 mmol/L glutamate for 24 hours. Damaged cells double-labeling with Hoechest33258 and PI were observed by fluorescence microscope. Ffluo-3 and CLSM for measurement of intracellular calcium levels were also utilized. RESULT: Most cells were damaged and the intracellular calcium increased and after exposure to 1 mmol/L glutamate (P < 0.05). CONCLUSION: Glutamate excitotoxicity was associated with free intracellular calcium ion concentration elevation in SGC.

[Excitotoxic effects of glutamate on the in vitro spiral ganglion cells] Publishing Authors By Initials

K Yan,Q Xue,L Luo,S Gong,

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[Excitotoxic effects of glutamate on the in vitro spiral ganglion cells] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Lin chuang er bi yan hou ke za zhi = Journal of cl

VOLUME: 20

Page Numbers: 611-3

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ISSN: 1001-1781

DAY: 19

MONTH: Jul

YEAR: 2006

[Excitotoxic effects of glutamate on the in vitro spiral ganglion cells] Information

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LANGUAGE: chi

NlmUniqueID: 9426080

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Grant and Affiliation Information for [Excitotoxic effects of glutamate on the in vitro spiral ganglion cells]

AFFILIATION: Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.

Country: China

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MEDLINETA: Lin Chuang Er Bi Yan Hou Ke Za

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