Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Abstract Text:

Excitotoxicity and disrupted energy metabolism are major events leading to nerve cell death in neurodegenerative disorders. These cooperative pathways share one common aspect: triggering of oxidative stress by free radical formation. In this work, we evaluated the effects of the antioxidant and energy precursor, levocarnitine (L-CAR), on the oxidative damage and the behavioral, morphological, and neurochemical alterations produced in nerve tissue by the excitotoxin and free radical precursor, quinolinic acid (2,3-pyrindin dicarboxylic acid; QUIN), and the mitochondrial toxin, 3-nitropropionic acid (3-NP). Oxidative damage was assessed by the estimation of reactive oxygen species formation, lipid peroxidation, and mitochondrial dysfunction in synaptosomal fractions. Behavioral, morphological, and neurochemical alterations were evaluated as markers of neurotoxicity in animals systemically administered with L-CAR, chronically injected with 3-NP and/or intrastriatally infused with QUIN. At micromolar concentrations, L-CAR reduced the three markers of oxidative stress stimulated by both toxins alone or in combination. L-CAR also prevented the rotation behavior evoked by QUIN and the hypokinetic pattern induced by 3-NP in rats. Morphological alterations produced by both toxins (increased striatal glial fibrillary acidic protein-immunoreactivity for QUIN and enhanced neuronal damage in different brain regions for 3-NP) were reduced by L-CAR. In addition, L-CAR prevented the synergistic action of 3-NP and QUIN to increase motor asymmetry and depleted striatal GABA levels. Our results suggest that the protective properties of L-CAR in the neurotoxic models tested are mostly mediated by its characteristics as an antioxidant agent.

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neurochemistry

VOLUME: 105

Page Numbers: 677-89

Journal Abbreviation: J. Neurochem.

ISSN: 1471-4159

DAY: 10

MONTH: 01

YEAR: 2008

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985190

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.

AFFILIATION: Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México, Mexico.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Neurochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine Related Publications

• After-hours discharge from intensive care: impact on outcome.
• An intensivist-led tracheostomy review team is associated with shorter decannulation time and length of stay: a prospective cohort study.
• Cesariella, a new genus of Laboulbeniales.
• Cholinesterase inhibitors improve survival in experimental sepsis: a new way to activate the cholinergic anti-inflammatory pathway.
• Cholinesterase inhibitors improve survival in experimental sepsis: a new way to activate the cholinergic anti-inflammatory pathway.
• Colossal ionic conductivity at interfaces of epitaxial ZrO2:Y2O3/SrTiO3 heterostructures.
• Comments on 'the great legalization debate'.
• Contrasting effects of invasive plants in plant-pollinator networks.
• Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats.
• Endoplasmic reticulum stress caused by overexpression of islet-specific glucose-6-phosphatase catalytic subunit-related protein in pancreatic Beta-cells.
• Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.
• Group 13 organoderivatives supported on a metallic oxide model.
• High-level overproduction of Thermus enzymes in Streptomyces lividans.
• How Drosophila change their combs: the Hox gene Sex combs reduced and sex comb variation among Sophophora species.
• Hypophosphatemia as unusual cause of ARDS in Cushing's syndrome secondary to ectopic CRH production. A case report.
• Initial models in conditionals: evidence from priming.
• Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.
• Kynurenine pathway and disease: an overview.
• Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder.
• Remifentanil and the brain.
• Report of an EFNS task force on management of sleep disorders in neurologic disease (degenerative neurologic disorders and stroke).
• Soret coefficients in some water-methanol, water-ethanol, and water-isopropanol systems.
• The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling.
• [Carotid angiography; notes on the topographic and histologic diagnosis of cerebral tumors.]
• [In vitro effects of azaserine on normal and neoplastic tissue; polarographic behavior of azaserine.]
• [New derivatives of benzothiazole. I. Synthesis.]
• [New derivatives of benzothiazole. II. Antibacterial action and influence on respiratory systems of animal cells.]
• [Not Available.]
• [Systemic symptoms, cough and cavitated pulmonary nodule in an untreated HIV patient.]
• [The photodynamic properties of thiacoumarin compounds; lethal effects on paramecia and polarographic measurement of photo-oxidation in blood serum.]