Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants.

Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants. Abstract Text:

Nancy F Krebs,Jamie L Westcott,Donna J Rodden,Katharine W Ferguson,Leland V Miller,K Michael Hambidge,

BACKGROUND: Small-for-gestational-age (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due to intrauterine factors or to high postnatal growth requirements is unknown. OBJECTIVE: We hypothesized that the size of the exchangeable zinc pool (EZP), which reflects metabolically available zinc, would be smaller in SGA than in appropriate-for-gestational-age (AGA) infants born prematurely. DESIGN: Intravenous 70Zn (45 microg/kg) was administered to 10 SGA infants (8 boys) with a mean (+/-SD) gestational age of 33.3 +/- 1.8 wk and to 11 AGA infants (8 boys) with a mean (+/-SD) gestational age of 32.4 +/- 1.2 wk within 24 h of birth. The EZP was determined from isotope enrichment in spot urine collections on days 3-7. RESULTS: The mean birth weight of the SGA infants was 1.30 +/- 0.2 kg and of the AGA infants was 1.84 +/- 0.3 kg (P = 0.0001). The EZP size was significantly smaller in the SGA than in the AGA infants on an absolute basis (13.3 +/- 2.8 and 25.2 +/- 8.1 mg; P = 0.0002) and relative to body weight (10.3 +/- 2.5 and 13.9 +/- 4.5 mg/kg; P = 0.02). The difference remained significant after adjustment for gestational age and birth weight. CONCLUSION: These data provide evidence for differential zinc status at birth between SGA and AGA infants born prematurely at similar stages of gestation and offer at least a partial explanation for the reported benefits of postnatal zinc supplementation.

Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants. Publishing Authors By Initials

NF Krebs,JL Westcott,DJ Rodden,KW Ferguson,LV Miller,KM Hambidge,

For similar inorganic chemicals: isotopes: zinc isotopes research abstracts see: inorganic chemicals: isotopes: zinc isotopes research

PUBMED ID PMID:

MEDLINE DATE:

Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of clinical nutrition

VOLUME: 84

Page Numbers: 1340-3

Journal Abbreviation: Am. J. Clin. Nutr.

ISSN: 0002-9165

DAY: 3

MONTH: Dec

YEAR: 2006

Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376027

Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants. Keywords Mesh Terms:

KEYWORDS: Zinc Isotopes

MESH TERMS: urine

Chemical & Substance for Abstract: Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants. Information

Substance Name: Zinc

Registry Number: 7440-66-6

Grant and Affiliation Information for Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants.

AFFILIATION: Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA. nancy.krebs@uchsc.edu

Country: United States

AGENCY: United States PHS

GRANT: U01-40657

ACRONYM: DK

MEDLINETA: Am J Clin Nutr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants Related Publications

• A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate.
• A population-based, multisite cohort study of the predictors of chronic idiopathic thrombocytopenic purpura in children.
• Complementary feeding: clinically relevant factors affecting timing and composition.
• Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants.
• Latino families report lower child injury rates than white families.
• Lower rates of emergency department injury visits among Latino children in the USA: no association with health insurance.
• Proper audits require specialist skills.
• Zinc and diarrhea.
• Zinc deficiency in the weanling--how important?
• Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia.