Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Research Abstract Details 

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Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Abstract Text:

Tony Velkov,James Horne,Aisha Laguerre,Eric Jones,Martin J Scanlon,Christopher J H Porter,Tony Velkov,James Horne,Aisha Laguerre,Eric Jones,Martin J Scanlon,Christopher J H Porter,

Transcellular diffusion across the absorptive epithelial cells (enterocytes) of the small intestine is the main route of absorption for most orally administered drugs. The process by which lipophilic compounds transverse the aqueous environment of the cytoplasm, however, remains poorly defined. In the present study, we have identified a structurally diverse group of lipophilic drugs that display low micromolar binding affinities for a cytosolic lipid-binding protein - intestinal fatty acid-binding protein (I-FABP). Binding to I-FABP significantly enhanced the transport of lipophilic drug molecules across a model membrane, and the degree of transport enhancement was related to both drug lipophilicity and I-FABP binding affinity. These data suggest that intracellular lipid-binding proteins such as I-FABP may enhance the membrane transport of lipophilic xenobiotics and facilitate drug access to the enterocyte cytoplasm and cytoplasmic organelles.

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Publishing Authors By Initials

T Velkov,J Horne,A Laguerre,E Jones,MJ Scanlon,CJ Porter,T Velkov,J Horne,A Laguerre,E Jones,MJ Scanlon,CJ Porter,

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Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemistry & biology

VOLUME: 14

Page Numbers: 453-65

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ISSN: 1074-5521

DAY: 27

MONTH: Apr

YEAR: 2007

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Information

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LANGUAGE: eng

NlmUniqueID: 9500160

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Grant and Affiliation Information for Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

AFFILIATION: Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia.

Country: England

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MEDLINETA: Chem Biol

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