Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice.

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. Abstract Text:

Koji Urano,Shuzo Suzuki,Kazuhiko Machida,Natsuko Eguchi,Nobuko Sawa,Koji Kikuchi,Yuji Hattori,Toshimi Usui,Koji Urano,Shuzo Suzuki,Kazuhiko Machida,Natsuko Eguchi,Nobuko Sawa,Koji Kikuchi,Yuji Hattori,Toshimi Usui,

We examined the possibility of expanding applications of rasH2 mice, which are genetically manipulated mice for short-term carcinogenicity tests, to percutaneous application. A 26-week short-term carcinogenicity study was performed on a total of 300 mice including 75 male and female rasH2 mice each, and 75 male and female non-Tg mice each from the same litter as the rasH2 mice divided into untreated group, an ethanol group, a white Vaseline group, an acetone group, and a phorbol 12-myristate 13-acetate (TPA) group. Only shaving of dorsal skin was performed on the untreated mice. As a positive control, TPA was administered percutaneously at a dose of 2.5 microg/kg and 3 times/week for 26 weeks based on the protocol for Tg.AC mice in the ILSI/HESI international validation study. In the ethanol, white Vaseline, and acetone groups, no tumorous changes were observed on the skin at the administration site. In the TPA group, nodular changes at the administration site were observed from seven weeks after the start of administration in rasH2 mice, and the incidence in males and females was 50.0% (7/14) and 53.3% (8/15), respectively. In a pathological examination, nodules in 21.4% (3/14) of males and 46.7% (7/15) of females were diagnosed as skin papilloma or keratoacanthoma, and the rest as squamous cell hyperplasia. In the non-Tg mice, no nodules or tumorigenic changes were observed at the administration site. These findings show that percutaneous application in rasH2 mice is possible in 26-week carcinogenicity tests.

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. Publishing Authors By Initials

K Urano,S Suzuki,K Machida,N Eguchi,N Sawa,K Kikuchi,Y Hattori,T Usui,K Urano,S Suzuki,K Machida,N Eguchi,N Sawa,K Kikuchi,Y Hattori,T Usui,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of toxicological sciences

VOLUME: 32

Page Numbers: 367-75

Journal Abbreviation:

ISSN: 0388-1350

DAY: 29

MONTH: Oct

YEAR: 2007

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7805798

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice.

AFFILIATION: Central Institute for Experimental Animals, Kawasaki, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Toxicol Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice Related Publications

• A case of hypertensive keratouveitis with endotheliitis associated with cytomegalovirus.
• Acute retinal necrosis in Japan.
• Biochemical properties of fibrinogen binding protein (clumping factor) of the staphylococcal cell surface.
• Cataract surgery using the bimanual phacoemulsification technique with an Accurus system and Mackool microphaco tip.
• Chemo-enzymatic synthesis of galactosylmaltooligosaccharidonolactone as a substrate analogue inhibitor for mammalian alpha-amylase.
• Circulating neutrophils in Behçet disease is resistant for apoptotic cell death in the remission phase of uveitis.
• Convenient synthesis of beta-(1-->3)-galactosyl disaccharide alpha-glycoside and its analogs as mimic units of mucin-type carbohydrate.
• Coxsackievirus B4 associated uveoretinitis in an adult.
• Effect of gauge thickness on wound-width measurements in microincision cataract surgery.
• Efficient synthesis of spacer-N-linked double-headed glycosides carrying N-acetylglucosamine and N,N'-diacetylchitobiose and their cross-linking activities with wheat germ agglutinin.
• Electrical double-layer interaction between oppositely charged dissimilar oxide surfaces with charge regulation and Stern-Grahame layers.
• Enzymatic Synthesis of Spacer-Linked Divalent Glycosides Carrying N-Acetylglucosamine and N-Acetyllactosamine: Analysis of Cross-Linking Activities with WGA.
• Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice.
• Further observations on the inhibiting effects of chromomycin A3 on transplantable tumors.
• Inguinal hernia after radical perineal prostatectomy: comparison with the retropubic approach.
• Lower urinary tract symptoms after radical perineal prostatectomy.
• Nickel and copper accumplation as essential elements in 10-A manganite of deep-sea manganese nodules.
• Overactive bladder in children should be strictly differentiated from monosymptomatic nocturnal enuresis.
• Renal artery pseudoaneurysm occurring after laparoscopic partial nephrectomy.
• Restoration of FGF receptor type 2 enhances radiosensitivity of hormone-refractory human prostate carcinoma PC-3 cells.
• Risk factors for intravesical recurrence following urothelial carcinoma of the upper urinary tract: no relationship to the mode of surgery.
• Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis.
• THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS WITH SPECIAL REFERENCE TO SEPARATION OF KETO BILE ACIDS.
• Transcription factors that regulate helper T cell differentiation.
• Videofunduscopy and videoangiography using the scanning laser ophthalmoscope in Vogt-Koyanagi-Harada syndrome.
• [Current treatment for malignant lymphomas.]
• [Epidemiological supplements on dysentery.]
• [Pseudoleukocytosis and pseudothrombocytosis caused by fragmentation of leukemic cells in tumor lysis syndrome]
• [Tuberculosis of the tongue.]
• p-nitrophenyl penta-N-acetyl-beta-chitopentaoside as a novel synthetic substrate for the colorimetric assay of lysozyme.