Exaggerated natriuresis in salt-sensitive essential hypertension.

Exaggerated natriuresis in salt-sensitive essential hypertension. Research Abstract Details 

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Exaggerated natriuresis in salt-sensitive essential hypertension. Abstract Text:

K D Wu,B S Hsieh,H F Tsai,Y M Chen,T S Chu,

Acute responses of blood pressure and natriuresis to intravenous injection of furosemide and saline infusion were evaluated in 38 patients with essential hypertension. Twelve patients whose mean arterial blood pressure decreased by more than 5% at two hours after intravenous administration of 20 mg furosemide were classified as salt-sensitive (SS); the remainders as salt-resistant (SR). The extent of natriuresis induced by furosemide was not different between the two subgroups. During 2-liter isotonic saline infusion the SS subjects excreted more sodium than the SR subjects did (108.7 +/- 11.9 vs 55.9 +/- 6.6 mmole, p less than 0.001). There was a significant correlation (r = 0.57, p less than 0.001) between the hypotensive effect of furosemide and the 4-hour sodium excretion during saline infusion. A reverse correlation between the sodium excretion during saline infusion and the increase in mean blood pressure at the end of infusion was shown in the SS subgroup (r = -0.72, p less than 0.01), but not in the SR subgroup (r = 0.045). The results suggest that prompt natriuresis on saline infusion in the SS hypertensives may function as a protective mechanism to prevent abrupt increase in blood volume and blood pressure during acute sodium loading.

Exaggerated natriuresis in salt-sensitive essential hypertension. Publishing Authors By Initials

KD Wu,BS Hsieh,HF Tsai,YM Chen,TS Chu,

For similar inorganic chemicals: sodium compounds: sodium, dietary research abstracts see: inorganic chemicals: sodium compounds: sodium, dietary research

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Exaggerated natriuresis in salt-sensitive essential hypertension. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 12

Page Numbers: 1395-403

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1990

Exaggerated natriuresis in salt-sensitive essential hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Exaggerated natriuresis in salt-sensitive essential hypertension. Keywords Mesh Terms:

KEYWORDS: Sodium, Dietary

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Exaggerated natriuresis in salt-sensitive essential hypertension. Information

Substance Name: Sodium Chloride

Registry Number: 7647-14-5

Grant and Affiliation Information for Exaggerated natriuresis in salt-sensitive essential hypertension.

AFFILIATION: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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