Evolving concepts in left ventricular systolic and diastolic remodeling: implications for therapy.

Evolving concepts in left ventricular systolic and diastolic remodeling: implications for therapy. Research Abstract Details 

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Evolving concepts in left ventricular systolic and diastolic remodeling: implications for therapy. Abstract Text:

W H Wilson Tang,Gary S Francis,

Left ventricular (LV) remodeling describes dynamic changes in ventricular size and shape that result from hemodynamic and metabolic insults to the failing heart. The remodeling hypothesis in heart failure asserts that LV remodeling is the central pathophysiologic lesion whereby alterations in cardiac structure are followed by impairment in function, with a wide range of genetic-environment interactions that determine the ultimate phenotype. Several therapeutic targets of LV remodeling have already been exploited (such as neurohormonal and cytokine activation). On the other hand, great efforts are still being made to understand the complex array of genetic and metabolic derangements. Nevertheless, we have realized that there is no single phenotypic change, protein expression, or signal-transduction pathway that is dominant in the process of cardiac remodeling. This implies that better characterization of this heterogeneous heart failure phenotype is desperately needed.

Evolving concepts in left ventricular systolic and diastolic remodeling: implications for therapy. Publishing Authors By Initials

WH Tang,GS Francis,

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Evolving concepts in left ventricular systolic and diastolic remodeling: implications for therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current cardiology reports

VOLUME: 6

Page Numbers: 200-4

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ISSN: 1523-3782

DAY: 12

MONTH: May

YEAR: 2004

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LANGUAGE: eng

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Grant and Affiliation Information for Evolving concepts in left ventricular systolic and diastolic remodeling: implications for therapy.

AFFILIATION: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA. tangw@ccf.org

Country: United States

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MEDLINETA: Curr Cardiol Rep

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