Evolutionary theory for modifiers of epistasis using a general symmetric model.

Evolutionary theory for modifiers of epistasis using a general symmetric model. Research Abstract Details 

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Evolutionary theory for modifiers of epistasis using a general symmetric model. Abstract Text:

Uri Liberman,Marcus W Feldman,

Genetic interactions in fitness are studied by using modifier theory. The effects on fitness of two linked genes are perturbed by alleles at a third linked locus that controls the extent of epistasis in fitness between the first two. This epistasis is determined by a symmetric interaction matrix, and it is shown that a modifier allele that increases epistasis will invade when the linkage between the other two genes is sufficiently tight and these genes are in linkage disequilibrium. With linkage equilibrium among the major loci, increased or decreased epistasis may evolve depending on the allele frequencies at these loci.

Evolutionary theory for modifiers of epistasis using a general symmetric model. Publishing Authors By Initials

U Liberman,MW Feldman,

For similar natural sciences: science: models, theoretical research abstracts see: natural sciences: science: models, theoretical research

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Evolutionary theory for modifiers of epistasis using a general symmetric model. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 19402-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 13

MONTH: 12

YEAR: 2006

Evolutionary theory for modifiers of epistasis using a general symmetric model. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Evolutionary theory for modifiers of epistasis using a general symmetric model. Keywords Mesh Terms:

KEYWORDS: Models, Theoretical

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Grant and Affiliation Information for Evolutionary theory for modifiers of epistasis using a general symmetric model.

AFFILIATION: School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel 69978.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 28016

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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