Evolutionary relationships of vertebrate NACHT domain-containing proteins.

Evolutionary relationships of vertebrate NACHT domain-containing proteins. Research Abstract Details 

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Evolutionary relationships of vertebrate NACHT domain-containing proteins. Abstract Text:

Austin L Hughes,

Phylogenetic analyses of conserved [neuronal apoptosis inhibitory protein (NAIP), MHC class II transcription activator (CIITA), incompatibility locus protein from Podospora anserina (HET-E), and telomerase-associated protein (TP1)] (NACHT) domains were used to reconstruct the evolutionary history of vertebrate NACHT-containing proteins. The results supported the hypothesis that NOD3 is basal to the other NACHT-containing proteins found in tetrapods. The latter formed two strongly supported clusters or subfamilies, here designated NALP and nucleotide-binding oligomerization domain (NOD). The presence of apparent bony fish orthologs of NOD3 and CIITA supported the hypothesis that the origin of these molecules predates the origin of tetrapods, and the presence of avian sequences in both NALP and NOD clusters supported the origin of these subfamilies before the bird-mammal divergence. However, the extensive diversification of the NALP subfamily seen in mammals evidently occurred within the mammalian lineage. Both NALP and NOD subfamilies include members with differential expression in the antigen-presenting cells of the immune system, and the phylogenetic analyses supported the hypothesis that this expression pattern has evolved independently more than once in each of these subfamilies.

Evolutionary relationships of vertebrate NACHT domain-containing proteins. Publishing Authors By Initials

AL Hughes,

For similar animals: chordata: vertebrates research abstracts see: animals: chordata: vertebrates research

PUBMED ID PMID:

MEDLINE DATE:

Evolutionary relationships of vertebrate NACHT domain-containing proteins. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Immunogenetics

VOLUME: 58

Page Numbers: 785-91

Journal Abbreviation: Immunogenetics

ISSN: 0093-7711

DAY: 28

MONTH: 09

YEAR: 2006

Evolutionary relationships of vertebrate NACHT domain-containing proteins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 420404

Evolutionary relationships of vertebrate NACHT domain-containing proteins. Keywords Mesh Terms:

KEYWORDS: Vertebrates

MESH TERMS: genetics

Chemical & Substance for Abstract: Evolutionary relationships of vertebrate NACHT domain-containing proteins. Information

Substance Name: Trans-Activators

Registry Number: 0

Grant and Affiliation Information for Evolutionary relationships of vertebrate NACHT domain-containing proteins.

AFFILIATION: Department of Biological Sciences, University of South Carolina, Coker Life Sciences Bldg, Columbia, SC 29208, USA. austin@biol.sc.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM43940

ACRONYM: GM

MEDLINETA: Immunogenetics

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