Evolutionary changes of metabolic networks and their biosynthetic capacities.

Evolutionary changes of metabolic networks and their biosynthetic capacities. Research Abstract Details 

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Evolutionary changes of metabolic networks and their biosynthetic capacities. Abstract Text:

O ,T Handorf,D Kahn,

The metabolic networks of different species show a large variety in their structural design. In this work, the evolution of functional properties of metabolism in relation with metabolic network structure is investigated. The metabolism of ancestral species is inferred from the metabolism of contemporary species using a Bayesian network model for metabolism evolution. Subsequently, these networks are analysed with the recently developed method of network expansion. This method allows for a structural analysis of metabolic networks as well as a quantification of network functions in terms of their synthesising capacities when they are provided with certain external resources. The evolutionary dynamics of one particular network function: the metabolic expansion of glucose is investigated.

Evolutionary changes of metabolic networks and their biosynthetic capacities. Publishing Authors By Initials

O ,T Handorf,D Kahn,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Evolutionary changes of metabolic networks and their biosynthetic capacities. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Systems biology

VOLUME: 153

Page Numbers: 354-8

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ISSN: 1741-2471

DAY: 7

MONTH: Sep

YEAR: 2006

Evolutionary changes of metabolic networks and their biosynthetic capacities. Information

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LANGUAGE: eng

NlmUniqueID: 101232067

Evolutionary changes of metabolic networks and their biosynthetic capacities. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Evolutionary changes of metabolic networks and their biosynthetic capacities. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Evolutionary changes of metabolic networks and their biosynthetic capacities.

AFFILIATION: Department of Biology, Humboldt University, Berlin, Germany. oliver.ebenhoeh@rz.hu-berlin.de

Country: England

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MEDLINETA: Syst Biol (Stevenage)

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