Evolution of the ventral midline in insect embryos.

Evolution of the ventral midline in insect embryos. Research Abstract Details 

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Evolution of the ventral midline in insect embryos. Abstract Text:

Robert P Zinzen,Jessica Cande,Matthew Ronshaugen,Dmitri Papatsenko,Mike Levine,

The ventral midline is a source of signals that pattern the nerve cord of insect embryos. In dipterans such as the fruitfly Drosophila melanogaster (D. mel.) and the mosquito Anopheles gambiae (A. gam.), the midline is narrow and spans just 1-2 cells. However, in the honeybee, Apis mellifera (A. mel.), the ventral midline is broad and encompasses 5-6 cells. slit and other midline-patterning genes display a corresponding expansion in expression. Evidence is presented that this difference is due to divergent cis regulation of the single-minded (sim) gene, which encodes a bHLH-PAS transcription factor essential for midline differentiation. sim is regulated by a combination of Notch signaling and a Twist (Twi) activator gradient in D. mel., but it is activated solely by Twi in A. mel. We suggest that the Twi-only mode of regulation--and the broad ventral midline--represents the ancestral form of CNS patterning in Holometabolous insects.

Evolution of the ventral midline in insect embryos. Publishing Authors By Initials

RP Zinzen,J Cande,M Ronshaugen,D Papatsenko,M Levine,

For similar proteins: dna-binding proteins: basic helix-loop-helix transcription factors: twist transcription factor research abstracts see: proteins: dna-binding proteins: basic helix-loop-helix transcription factors: twist transcription factor research

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Evolution of the ventral midline in insect embryos. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental cell

VOLUME: 11

Page Numbers: 895-902

Journal Abbreviation: Dev. Cell

ISSN: 1534-5807

DAY: 3

MONTH: Dec

YEAR: 2006

Evolution of the ventral midline in insect embryos. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101120028

Evolution of the ventral midline in insect embryos. Keywords Mesh Terms:

KEYWORDS: Twist Transcription Factor

MESH TERMS: metabolism

Chemical & Substance for Abstract: Evolution of the ventral midline in insect embryos. Information

Substance Name: sim protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Evolution of the ventral midline in insect embryos.

AFFILIATION: Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, California 94720, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 46638

ACRONYM: GM

MEDLINETA: Dev Cell

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