Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy.

Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy. Research Abstract Details 

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Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy. Abstract Text:

Mitsushige Sugimoto,Takahisa Furuta,Naohito Shirai,Chise Kodaira,Masafumi Nishino,Mutsuhiro Ikuma,Takashi Ishizaki,Akira Hishida,Mitsushige Sugimoto,Takahisa Furuta,Naohito Shirai,Chise Kodaira,Masafumi Nishino,Mutsuhiro Ikuma,Takashi Ishizaki,Akira Hishida,

BACKGROUNDS AND AIMS: Eradication rates of Helicobacter pylori by a proton pump inhibitor-based triple therapy depend on CYP2C19 genotype status. We investigated whether gastric acid inhibition during an eradication therapy would influence the eradication rates attained by the triple therapy. METHODS: Thirty-two patients with H. pylori infection underwent the first-line triple therapy with lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 400 mg b.i.d. for 1 week. In all 32 patients, the 24-hour intragastric pH monitoring was performed on day 6 during the treatment period. RESULTS: The intention-to-treat-based eradication rate by the first-line therapy was 75.0% (24/32, 95%CI: 56.60-88.54%). In patients with successful eradication, the median 24-hour pH was 6.4 (range; 5.0-7.6), which was significantly higher than that in patients without eradication [5.2 (2.2-6.2), p = .0131]. The median percentage time of pH < 4.0 during 24-hour postdose in patients with eradication [0.5% (0.0-31.6%)] was significantly shorter than that in patients without eradication [26.7% (6.0-72.2%), p = .0017]. These parameters for acid inhibition significantly differed among the different CYP2C19 genotype groups. When the percentage time of pH < 4.0 and 24-hour pH were attained < 10% and > 6.0, respectively, during the eradication treatment, the majority of patients could eradicate H. pylori infection, irrespective of the bacterial susceptibility to clarithromycin. CONCLUSIONS: The sustained intragastric pH > 4.0 for a longer postdose time appears to be required for a successful eradication of H. pylori with lansoprazole and acid-labile antibiotics.

Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy. Publishing Authors By Initials

M Sugimoto,T Furuta,N Shirai,C Kodaira,M Nishino,M Ikuma,T Ishizaki,A Hishida,M Sugimoto,T Furuta,N Shirai,C Kodaira,M Nishino,M Ikuma,T Ishizaki,A Hishida,

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Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Helicobacter

VOLUME: 12

Page Numbers: 317-23

Journal Abbreviation: Helicobacter

ISSN: 1083-4389

DAY: 2

MONTH: Aug

YEAR: 2007

Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy. Information

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LANGUAGE: eng

NlmUniqueID: 9605411

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Grant and Affiliation Information for Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy.

AFFILIATION: First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. mitsu@hama-med.ac.jp

Country: United States

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MEDLINETA: Helicobacter

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