Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors.

Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors. Research Abstract Details 

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Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors. Abstract Text:

PURPOSE: Stereotactic radiotherapy (SRT) is fast becoming the method of choice for treatment of nonsuperficial brain lesions. SRT treatment plans of malignant brain tumors typically incorporate a 20-mm isotropic margin to account for microscopic tumor spread; however, distant or progressive tumors occur outside this margin. Our hypothesis is that paths of elevated water diffusion may provide a preferred route for transport or migration of cancer cells. If our hypothesis is correct, then future SRT treatment volumes could be modified to provide elongated treatment margins along the paths of elevated water diffusion, thereby creating a biologically better treatment plan that may reduce the incidence of progression. METHODS AND MATERIALS: Magnetic resonance diffusion tensor imaging (DTI) datasets were acquired on patient subjects before the appearance of >5 mm diameter progressive lesions or secondary tumors. DTI was performed using an echo-planar imaging sequence on a 1.5T clinical General Electric scanner with voxel dimensions of 0.98 x 0.98 x 6 mm. After SRT, patients were given repeated magnetic resonance imaging follow-ups at regular intervals to identify early tumor progression. When progressive disease was detected, DTIstudio and FMRIB Software Library software was used to compute paths of preferred water diffusion through the primary tumor site and the site of progression. RESULTS: Our preliminary results on 14 patient datasets suggest a strong relationship between routes of elevated water diffusion from the primary tumor and the location of tumor progression. CONCLUSIONS: Further investigation is therefore warranted. Future work will employ more sophisticated fiber analysis in a prospective study.

Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors. Publishing Authors By Initials

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Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of radiation oncology, biolo

VOLUME: 71

Page Numbers: 1553-62

Journal Abbreviation: Int. J. Radiat. Oncol. Biol. P

ISSN: 0360-3016

DAY: 4

MONTH: 06

YEAR: 2008

Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors. Information

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LANGUAGE: eng

NlmUniqueID: 7603616

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Grant and Affiliation Information for Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors.

AFFILIATION: Department of Biomedical Engineering, University of Rochester, Rochester, NY.

Country: United States

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MEDLINETA: Int J Radiat Oncol Biol Phys

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