Evidence that long-term potentiation occurs within individual hippocampal synapses during learning.

Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. Research Abstract Details 

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Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. Abstract Text:

Vadim Fedulov,Christopher S Rex,Danielle A Simmons,Linda Palmer,Christine M Gall,Gary Lynch,

Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin polymerization. We used one of these, involving phosphorylation of the regulatory protein cofilin, as a marker to test whether LTP-related changes occur in hippocampal synapses during unsupervised learning. Well handled rats were allowed to explore a compartmentalized environment for 30 min after an injection of vehicle or the NMDA receptor antagonist (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP). Another group of rats consisted of vehicle-injected, home-cage controls. Vehicle-treated rats that explored the environment had 30% more spines with dense phosphorylated (p) cofilin immunoreactivity in hippocampal field CA1 than did rats in the home-cage group. The increase in pCofilin-positive spines and behavioral evidence for memory of the explored environment were both eliminated by CPP. Coimmunostaining for pCofilin and the postsynaptic density protein 95 (PSD-95) showed that synapses on pCofilin-positive spines were substantially larger than those on neighboring (pCofilin-negative) spines. These results establish that uncommon cellular events associated with LTP, including changes in synapse size, occur in individual spines during learning, and provide a technique for mapping potential engrams.

Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. Publishing Authors By Initials

V Fedulov,CS Rex,DA Simmons,L Palmer,CM Gall,G Lynch,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 8031-9

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 25

MONTH: Jul

YEAR: 2007

Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. Information

Substance Name: 3-(2-carboxypiperazin-4-yl)propyl-1-phos

Registry Number: 100828-16-8

Grant and Affiliation Information for Evidence that long-term potentiation occurs within individual hippocampal synapses during learning.

AFFILIATION: Department of Anatomy and Neurobiology, University of California, Irvine, California 92617-4291, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS051823

ACRONYM: NS

MEDLINETA: J Neurosci

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