Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer.

Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Abstract Text:

Low selenium (Se) status has been associated with increased risk of colorectal cancer (CRC). Se is present as the amino acid selenocysteine in selenoproteins, such as the glutathione peroxidases. Se incorporation requires specific RNA structures in the 3' untranslated region (3'UTR) of the selenoprotein mRNAs. A single nucleotide polymorphism (SNP) occurs at nucleotide 718 (within the 3'UTR) in the glutathione peroxidase 4 gene. In the present study, Caco-2 cells were transfected with constructs in which type 1 iodothyronine deiodinase coding region was linked to the GPx4 3'UTR with either C or T variant at position 718. Higher reporter activity was observed in cells expressing the C variant compared to those expressing the T variant, under either Se-adequate or Se-deficient conditions. In addition, a disease association study was carried out in cohorts of patients with either adenomatous polyps, colorectal adenocarcinomas and in healthy controls. A higher proportion of individuals with CC genotype at the GPx4 T/C 718 SNP was present in the cancer group, but not in the polyp group, compared with the control group (P < 0.05). The present data demonstrate the functionality of the GPx4 T/C 718 SNP and suggest that T genotype is associated with lower risk of CRC.

Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genes & nutrition

VOLUME: 2

Page Numbers: 225-32

Journal Abbreviation:

ISSN: 1555-8932

DAY: 13

MONTH: 10

YEAR: 2007

Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101280108

Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer.

AFFILIATION: School of Life Sciences, The Robert Gordon University, Aberdeen, AB25 1HG, UK.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Genes Nutr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer Related Publications

• Birth and re-birth.
• Causes and treatment of ulnar nerve paralysis.
• Chemotherapy-induced nausea and vomiting.
• EXPERIENCES WITH THE THOMPSON QUADRICEPSPLASTY.
• Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer.
• Fowl peritoneal exudate cells: Collection and use for the macrophage migration inhibition test.
• Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex.
• Fungous infections; the superficial and deep mycoses.
• Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study).
• INTRA-UTERINE AMPUTATIONS AND ANNULAR LIMB DEFECTS IN SINGAPORE.
• Marasmus.
• Neurosis in the factory.
• No evidence of the Chlamydia trachomatis variant in the UK.
• Novel neurokinin-1 antagonists as antiemetics for the treatment of chemotherapy-induced emesis.
• Nutrigenomics and selenium: gene expression patterns, physiological targets, and genetics.
• Palliative care in the cancer patient.
• Preschool children and physical activity a review of correlates.
• Staufen1 is expressed in preimplantation mouse embryos and is required for embryonic stem cell differentiation.
• Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes.
• Targeting of transcripts encoding membrane proteins in polarized epithelia: RNA-protein binding studies of the SGLT1 3'-UTR.
• The management of primary adenocarcinoma of the vermiform appendix.
• The mental health status of Chinese rural-urban migrant workers : comparison with permanent urban and rural dwellers.