Evidence of recombination within human alpha-papillomavirus.

Evidence of recombination within human alpha-papillomavirus. Research Abstract Details 

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Evidence of recombination within human alpha-papillomavirus. Abstract Text:

Manuel Angulo,Antonio ,

BACKGROUND: Human papillomavirus (HPV) has a causal role in cervical cancer with almost half a million new cases occurring each year. Presence of the carcinogenic HPV is necessary for the development of the invasive carcinoma of the genital tract. Therefore, persistent infection with carcinogenic HPV causes virtually all cervical cancers. Some aspects of the molecular evolution of this virus, as the putative importance of recombination in its evolutionary history, are an opened current question. In addition, recombination could also be a significant issue nowadays since the frequency of co-infection with more than one HPV type is not a rare event and, thus, new recombinant types could be currently being generated. RESULTS: We have used human alpha-PV sequences from the public database at Los Alamos National Laboratory to report evidence that recombination may exist in this virus. A model-based population genetic approach was used to infer the recombination signal from the HPV DNA sequences grouped attending to phylogenetic and epidemiological information, as well as to clinical manifestations. Our results agree with recently published ones that use a different methodology to detect recombination associated to the gene L2. In addition, we have detected significant recombination signal in the genes E6, E7, L2 and L1 at different groups, and importantly within the high-risk type HPV16. The method used has recently been shown to be one of the most powerful and reliable procedures to detect the recombination signal. CONCLUSION: We provide new support to the recent evidence of recombination in HPV. Additionally, we performed the recombination estimation assuming the best-fit model of nucleotide substitution and rate variation among sites, of the HPV DNA sequence sets. We found that the gene with recombination in most of the groups is L2 but the highest values were detected in L1 and E6. Gene E7 was recombinant only within the HPV16 type. The topic deserves further study because recombination is an important evolutionary mechanism that could have high impact both in pharmacogenomics (i.e. on the influence of genetic variation on the response to drugs) and for vaccine development.

Evidence of recombination within human alpha-papillomavirus. Publishing Authors By Initials

M Angulo,A ,

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Evidence of recombination within human alpha-papillomavirus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Virology journal

VOLUME: 4

Page Numbers: 33

Journal Abbreviation:

ISSN: 1743-422X

DAY: 28

MONTH: 03

YEAR: 2007

Evidence of recombination within human alpha-papillomavirus. Information

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LANGUAGE: eng

NlmUniqueID: 101231645

Evidence of recombination within human alpha-papillomavirus. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Evidence of recombination within human alpha-papillomavirus. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Evidence of recombination within human alpha-papillomavirus.

AFFILIATION: Department of pathology, Complejo Hospitalario Universitario de Vigo, 36204 Vigo, Spain. mangcou1@sergas.es <mangcou1@sergas.es>

Country: England

AGENCY: United States NIGMS

GRANT: R01-GM66276

ACRONYM: GM

MEDLINETA: Virol J

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