Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland.

Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Research Abstract Details 

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Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Abstract Text:

A Teymoortash,C Schrader,H Shimoda,S Kato,J A Werner,A Teymoortash,C Schrader,H Shimoda,S Kato,J A Werner,

The details of the pathogenesis of cystadenolymphoma (Warthin's tumor) of the parotid gland are still unclear. Neovascularization is considered to be a pivotal factor for solid tumor progression and biological behavior of the tumor. Using double-labeling immunohistochemistry for LYVE-1 and CD34 (specific markers for lymphatic and vascular endothelial cells, respectively) this study analyzes lymphatic vessel density (LVD) and blood vessel density (BVD) in 10 Warthin's tumors and 10 pleomorphic adenomas of the parotid gland as well as in 5 normal parotid glands and 5 normal parotid lymph nodes. There was no significant difference in the intratumoral LVD and BVD among pleomorphic adenoma and normal parotid gland tissue. In contrast, the intratumoral LVD and BVD were significantly higher in Warthin's tumor than pleomorphic adenoma, normal parotid gland and parotid lymph node (P<0.0001 versus P<0.004). The increase in lymphatic vessels in Warthin's tumor suggests that epithelial tumor cells might promote lymphangiogenesis in this kind of lesions.

Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Publishing Authors By Initials

A Teymoortash,C Schrader,H Shimoda,S Kato,JA Werner,A Teymoortash,C Schrader,H Shimoda,S Kato,JA Werner,

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Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oral oncology

VOLUME: 43

Page Numbers: 614-8

Journal Abbreviation: Oral Oncol.

ISSN: 1368-8375

DAY: 25

MONTH: 09

YEAR: 2006

Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Information

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LANGUAGE: eng

NlmUniqueID: 9709118

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AFFILIATION: Department of Otolaryngology, Head and Neck Surgery, Philipp University, Deutschhausstr. 3, 35037 Marburg, Germany. teymoort@med.uni-marburg.de

Country: England

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MEDLINETA: Oral Oncol

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