Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications.

Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications. Research Abstract Details 

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Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications. Abstract Text:

Sridevi Devaraj,Anthony T Cheung,Ishwarlal Jialal,Steven C Griffen,Danh Nguyen,Nicole Glaser,Thomas Aoki,Sridevi Devaraj,Anthony T Cheung,Ishwarlal Jialal,Steven C Griffen,Danh Nguyen,Nicole Glaser,Thomas Aoki,

OBJECTIVE: Type 1 diabetes is associated with increased microvascular complications and inflammation. The monocyte-macrophage is a pivotal cell in atherogenesis. There are scanty data on noninvasive measures of microvascular abnormalities and inflammation in type 1 diabetic subjects with microvascular complications. Thus, we examined systemic and cellular biomarkers of inflammation in type 1 diabetic patients with microvascular complications (T1DM-MV patients) and type 1 diabetic patients without microvascular complications (T1DM patients) compared with matched control subjects and determined the microcirculatory abnormalities in the T1DM and T1DM-MV patients using computer-assisted intravital microscopy (CAIM). RESEARCH DESIGN AND METHODS: Fasting blood, 24-h urine, and CAIM measurements were obtained from the T1DM and T1DM-MV patients and matched control subjects. C-reactive protein, E-selectin, nitrotyrosine, monocyte superoxide, and cytokines were elevated in the T1DM and T1DM-MV patients compared with control subjects (P < 0.01). RESULTS: Severity index, as assessed by CAIM, was significantly increased in the T1DM and T1DM-MV patients compared with the control subjects (P < 0.001). There was a significant increase in C-reactive protein, nitrotyrosine, vascular cell adhesion molecule and monocyte superoxide anion release, and interleukin-1 release in T1DM-MV compared with T1DM patients (P < 0.05). T1DM-MV patients had significantly increased CAIM severity index and microalbumin-to-creatinine ratio compared with T1DM patients (P < 0.05). Furthermore, pp38MAPK, pp65, and pERK activity were significantly increased in monocytes from the T1DM and T1DM-MV patients compared with those from the controls subjects, and pp38MAPK and pp65 activity were significantly increased in the T1DM-MV compared with the T1DM patients (P < 0.01). CONCLUSIONS: T1DM-MV patients have increased inflammation compared with T1DM patients. CAIM provides an effective biomarker of microvascular complications, since it is significantly elevated in T1DM-MV compared with T1DM patients and can be monitored following therapies targeted at improving inflammation and/or microvascular complications of type 1 diabetes.

Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications. Publishing Authors By Initials

S Devaraj,AT Cheung,I Jialal,SC Griffen,D Nguyen,N Glaser,T Aoki,S Devaraj,AT Cheung,I Jialal,SC Griffen,D Nguyen,N Glaser,T Aoki,

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Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Diabetes

VOLUME: 56

Page Numbers: 2790-6

Journal Abbreviation: Diabetes

ISSN: 1939-327X

DAY: 8

MONTH: 08

YEAR: 2007

Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications. Information

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LANGUAGE: eng

NlmUniqueID: 372763

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AFFILIATION: Department of Pathology, Laboratory for Atherosclerosis and Metabolic Research, UCDavis Medical Center, Sacramento, CA 95817, USA. sdevaraj@ucdavis.edu

Country: United States

AGENCY: United States NCRR

GRANT: UL1 RR024146

ACRONYM: RR

MEDLINETA: Diabetes

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