Evidence of depressive symptoms in fragile-X syndrome premutated females.

Evidence of depressive symptoms in fragile-X syndrome premutated females. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Evidence of depressive symptoms in fragile-X syndrome premutated females. Abstract Text:

OBJECTIVES: Fragile-X premutation carriers have been considered asymptomatic patients for a long time. It has been, however, demonstrated that the premutation is also involved in clinical pathology, such as premature ovarian failure, the fragile-X-associated tremor/ataxia syndrome, and a distinct neurocognitive and behavioral phenotype, which includes psychiatric problems. To define better this neuropsychiatric phenotype associated with premutation carriers and to minimize a possible environmental effect, we examined psychiatric and depressive symptoms in 34 FMR1 premutation carrier mothers of children with fragile-X syndrome in comparison with two control groups (39 mothers with a non-fragile-X syndrome mentally retarded child and 39 mothers from the general population). METHODS: All participants completed both questionnaires, which assess psychiatric symptoms (the symptom checklist-90-revised) and depression (Beck Depression Inventory). RESULTS: Both groups of mothers with a mentally retarded child showed greater susceptibility to psychological problems than the control group without a mentally retarded child, but FMR1 premutated mothers evidenced a higher tendency to depression. These results suggest that, despite the stress of caring for a child with mental retardation, the premutation by itself could be responsible for some psychiatric traits. CONCLUSION: Our findings reinforce the hypothesis of a pathogenic gene-brain-behavior mechanism in the premutation range.

Evidence of depressive symptoms in fragile-X syndrome premutated females. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Evidence of depressive symptoms in fragile-X syndrome premutated females. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatric genetics

VOLUME: 18

Page Numbers: 153-5

Journal Abbreviation: Psychiatr. Genet.

ISSN: 1473-5873

DAY: 16

MONTH: Aug

YEAR: 2008

Evidence of depressive symptoms in fragile-X syndrome premutated females. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9106748

Evidence of depressive symptoms in fragile-X syndrome premutated females. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Evidence of depressive symptoms in fragile-X syndrome premutated females. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Evidence of depressive symptoms in fragile-X syndrome premutated females.

AFFILIATION: Biochemistry and Molecular Genetics Department, Hospital Clínic and IDIBAPS, Barcelona, Spain.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Psychiatr Genet

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Evidence of depressive symptoms in fragile-X syndrome premutated females Related Publications

• A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa.
• A novel mutation in JARID1C gene associated with mental retardation.
• Deletion of the OPHN1 gene detected by aCGH.
• Elastin mutation screening in a group of patients affected by vascular abnormalities.
• Evidence of depressive symptoms in fragile-X syndrome premutated females.
• FXTAS in spanish patients with ataxia: support for female FMR1 premutation screening.
• Ising phases of Heisenberg ladders in a magnetic field.
• Quantum and thermal transitions out of the supersolid phase of a 2D quantum antiferromagnet.
• Supersolid phase induced by correlated hopping in spin-1/2 frustrated quantum magnets.
• X-chromosome tiling path array detection of copy number variants in patients with chromosome X-linked mental retardation.
• [Hereditary juvenile progressive general paralysis; prophylactic considerations.]