Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3.

Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. Research Abstract Details 

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Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. Abstract Text:

Pushpa Jayaraman,Tuofu Zhu,Lynda Misher,Deepika Mohan,LaRene Kuller,Patricia Polacino,Barbra A Richardson,Helle Bielefeldt-Ohmann,David Anderson,Shiu-Lok Hu,Nancy L Haigwood,

To model human immunodeficiency virus (HIV) perinatal transmission, we studied infection of simian-human immunodeficiency virus (SHIV) SF162P3 in 10 pregnant Macaca nemestrina females and their offspring. Four of nine infants born to and suckled by these dams had evidence of infection, a transmission rate of 44.4% (95% confidence interval, 13.7% to 78.8%). We quantified transplacentally acquired and de novo Env-specific immunoglobulin G (IgG), IgM, and neutralizing antibodies in newborns. Transmission of escape variants was confirmed. In utero infection (n = 1) resulted in high viremia, depletion of peripheral CD4+ T cells, and rapid evolution of env in blood and tissues. Peripartum or postpartum SHIV infection (n = 3) resulted in postacute viral control that was undetectable by very sensitive multiplex PCR, despite increasing antibodies. Seropositive infants with highly controlled viremia had homogeneous peripheral blood env sequences, and their tissues had <3 copies per million cells. A high incidence of seropositive virus-low or -negative SHIV infection in infant macaques has implications for HIV type 1 perinatal transmission and detection.

Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. Publishing Authors By Initials

P Jayaraman,T Zhu,L Misher,D Mohan,L Kuller,P Polacino,BA Richardson,H Bielefeldt-Ohmann,D Anderson,SL Hu,NL Haigwood,

For similar virus diseases: viremia research abstracts see: virus diseases: viremia research

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Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 822-34

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 1

MONTH: 11

YEAR: 2006

Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. Keywords Mesh Terms:

KEYWORDS: Viremia

MESH TERMS: virology

Chemical & Substance for Abstract: Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3. Information

Substance Name: Immunoglobulin M

Registry Number: 0

Grant and Affiliation Information for Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3.

AFFILIATION: Departments of Pathobiology, National Primate Research Center, University of Washington, Seattle, Washington 98195, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR00166

ACRONYM: RR

MEDLINETA: J Virol

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ACCESSION NUMBER: DQ863102

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