Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder.

Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Abstract Text:

Carrie E Bearden,David C Glahn,Sheila Caetano,Rene L Olvera,Manoela Fonseca,Pablo Najt,Kristina Hunter,Steve R Pliszka,Jair C Soares,Carrie E Bearden,David C Glahn,Sheila Caetano,Rene L Olvera,Manoela Fonseca,Pablo Najt,Kristina Hunter,Steve R Pliszka,Jair C Soares,

OBJECTIVES: Systematic parsing of executive function processes is critical for the development of more specific models of neurobiological processes mediating disturbed cognition in youth with bipolar disorder (BPD). METHODS: A sample of 33 children and adolescents with bipolar I disorder (BPD I) (mean age 12.1 +/- 3.0 years, 39% female) and 44 demographically matched healthy participants (mean age 12.9 +/- 2.8 years, 50% female) completed a neurocognitive battery including measures aimed at detection of disruption in prefrontal cortical circuitry (i.e., working memory, set shifting, and rule attainment). RESULTS: Compared to healthy controls, BPD I children exhibited significant deficits in spatial working memory, visual sequencing and scanning, verbal fluency and abstract problem solving, particularly when a memory component was involved. In our spatial delayed response task, memory set size was parametrically varied; the performance pattern in BPD I children suggested deficits in short-term memory encoding and/or storage, rather than capacity limitations in spatial working memory. Earlier age at onset of illness and antipsychotic medication usage were associated with poorer performance on speeded information-processing tasks; however, severity of mood symptomatology and comorbidity with disruptive behavior disorders were not associated with task performance. CONCLUSIONS: These results suggest impairment in measures of prefrontal cortical function in juvenile BPD I that are similar to those seen in the adult form of the illness, and implicate both the ventral and dorsolateral prefrontal cortex as loci of pathology in juvenile BPD. As these deficits were not associated with clinical state or comorbidity with other disorders, they may reflect trait-related impairments, a hypothesis that will be pursued further in longitudinal studies.

Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Publishing Authors By Initials

CE Bearden,DC Glahn,S Caetano,RL Olvera,M Fonseca,P Najt,K Hunter,SR Pliszka,JC Soares,CE Bearden,DC Glahn,S Caetano,RL Olvera,M Fonseca,P Najt,K Hunter,SR Pliszka,JC Soares,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bipolar disorders

VOLUME: 9 Suppl 1

Page Numbers: 145-59

Journal Abbreviation: Bipolar Disord

ISSN: 1398-5647

DAY: 4

MONTH: Jun

YEAR: 2007

Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883596

Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder.

AFFILIATION: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA. cbearden@mednet.ucla.edu

Country: Denmark

AGENCY: United States NCRR

GRANT: RR-020571

ACRONYM: RR

MEDLINETA: Bipolar Disord

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder Related Publications

• A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor.
• Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study.
• An annotated cDNA library of juvenile Euprymna scolopes with and without colonization by the symbiont Vibrio fischeri.
• Anatomical measurements of the orbitofrontal cortex in child and adolescent patients with bipolar disorder.
• Angiogenesis and chronic inflammation: cause or consequence?
• Anti-proliferative effect of the essential oil of Cymbopogon citratus (DC) Stapf (lemongrass) on intracellular amastigotes, bloodstream trypomastigotes and culture epimastigotes of Trypanosoma cruzi (Protozoa: Kinetoplastida).
• Association between the presence of serum antibodies against Neospora spp. and fetal loss in equines.
• Chromosomal analysis of Barrett's cells: demonstration of instability and detection of the metaplastic lineage involved.
• Context processing performance in bipolar disorder patients.
• Cortical sulci and bipolar disorder.
• Effect of sphingosine and phorbol-12-myristate-13-acetate on the growth and dimethylsulfoxide-induced differentiation in the insect trypanosomatid Herpetomonas samuelpessoai.
• Efficacy of 2,6-dichlorophenol lure to control Dermacentor nitens.
• Evaluation of the acaricide effect of thymol, menthol, salicylic acid, and methyl salicylate on Boophilus microplus (Canestrini 1887) (Acari: Ixodidae) larvae.
• Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder.
• Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder.
• Greater cortical gray matter density in lithium-treated patients with bipolar disorder.
• Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation.
• Human salivary gland branching morphogenesis: morphological localization of claudins and its parallel relation with developmental stages revealed by expression of cytoskeleton and secretion markers.
• Impulsivity and bipolar disorder.
• Influence of the shape core on custom cast dowel and core removal by ultrasonic energy.
• Low levels of N-acetyl aspartate in the left dorsolateral prefrontal cortex of pediatric bipolar patients.
• MRI study of corpus callosum in patients with borderline personality disorder: a pilot study.
• MRI study of thalamus volumes in juvenile patients with bipolar disorder.
• Nursing, environment and health conceptions: an ecosystemic approach of the collective health production in the primary care.
• Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder.
• Pregnancy in the brown Norway rat: a model for investigating the genetics of placentation.
• Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia.
• Trait impulsivity in patients with mood disorders.
• [Correlation of dyslipidemia in patients with critical ischemia in Hospital Barão de Lucena - Recife/PE]
• [Training and challenges for the health care system in Brazil: an analysis of investments to expand health care service delivery]