Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS.

Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS. Research Abstract Details 

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Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS. Abstract Text:

Mili Kapoor,Quansheng Zhou,Francella Otero,Christopher A Myers,Alison Bates,Rajesh Belani,Jianming Liu,Jiann-Kae Luo,Eleni Tzima,Dong-Er Zhang,Xiang-Lei Yang,Paul Schimmel,Mili Kapoor,Quansheng Zhou,Francella Otero,Christopher A Myers,Alison Bates,Rajesh Belani,Jianming Liu,Jiann-Kae Luo,Eleni Tzima,Dong-Er Zhang,Xiang-Lei Yang,Paul Schimmel,Mili Kapoor,Quansheng Zhou,Francella Otero,Christopher A Myers,Alison Bates,Rajesh Belani,Jianming Liu,Jiann-Kae Luo,Eleni Tzima,Dong-Er Zhang,Xiang-Lei Yang,Paul Schimmel,

In mammalian cells, specific aminoacyl-transfer RNA (tRNA) synthetases have cytokine functions that require interactions with partners outside of the translation apparatus. Little is known about these interactions and how they facilitate expanded functions that link protein translation to other cellular pathways. For example, an alternative splice fragment of tryptophanyl-tRNA synthetase (TrpRS) and a similar natural proteolytic fragment are potent angiostatic factors that act through the vascular endothelial-cadherin receptor and Akt signaling pathway. Here we demonstrate mobilization of TrpRS for exocytosis from endothelial cells and the potential for plasmin to activate the cytokine function of the extracellular synthetase. Direct physical evidence showed that the annexin II-S100A10 complex, which regulates exocytosis, forms a ternary complex with TrpRS. Functional studies demonstrate that both annexin II and S100A10 regulate trafficking of TrpRS. Thus, complexes of mammalian tRNA synthetases with seemingly disparate proteins may in general be relevant to understanding how their expanded functions are implemented.

Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS. Publishing Authors By Initials

M Kapoor,Q Zhou,F Otero,CA Myers,A Bates,R Belani,J Liu,JK Luo,E Tzima,DE Zhang,XL Yang,P Schimmel,M Kapoor,Q Zhou,F Otero,CA Myers,A Bates,R Belani,J Liu,JK Luo,E Tzima,DE Zhang,XL Yang,P Schimmel,M Kapoor,Q Zhou,F Otero,CA Myers,A Bates,R Belani,J Liu,JK Luo,E Tzima,DE Zhang,XL Yang,P Schimmel,

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Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 283

Page Numbers: 2070-7

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 13

MONTH: 11

YEAR: 2007

Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

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Grant and Affiliation Information for Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS.

AFFILIATION: Department of Molecular Biology, The Skaggs Institute for Chemical Biology.

Country: United States

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MEDLINETA: J Biol Chem

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