Evidence for a role of nicotinic acetylcholine receptors in schizophrenia.

Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Research Abstract Details 

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Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Abstract Text:

Catherine E Adams,Karen E Stevens,

Schizophrenia is a debilitating, complex and costly illness affecting roughly 1% of the world's inhabitants. The excessive degree of cigarette smoking exhibited by schizophrenic patients suggests that they might be self-medicating to ameliorate certain aspects of the characteristic positive, negative and cognitive symptoms associated with the disease. Morphological examinations found alterations in nicotinic receptors in postmortem tissue from schizophrenic individuals compared to controls, especially in the a7 and a4b2 subtypes. These data were consistent with molecular biology studies which demonstrated associations between polymorphisms in gene coding for these receptors and schizophrenia. In studies of nicotinic receptor stimulation in schizophrenia patients, improvement in sensory inhibition and cognitive deficits were observed following treatment, though the effects were transient. These results have spurred the development of new pharmaceuticals specifically designed to modulate nicotinic receptor function. The initial results from clinical trials of these new drugs appear promising, potentially opening new avenues of treatment for this devastating disease.

Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Publishing Authors By Initials

CE Adams,KE Stevens,

For similar behavior and behavior mechanisms: behavior: habits: smoking research abstracts see: behavior and behavior mechanisms: behavior: habits: smoking research

PUBMED ID PMID:

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Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 12

Page Numbers: 4755-72

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 05

YEAR: 2007

Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Information

Number of References: 225

LANGUAGE: eng

NlmUniqueID: 9709506

Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Keywords Mesh Terms:

KEYWORDS: Smoking

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Information

Substance Name: Receptors, Nicotinic

Registry Number: 0

Grant and Affiliation Information for Evidence for a role of nicotinic acetylcholine receptors in schizophrenia.

AFFILIATION: Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, USA. cathy.adams@uchsc.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH068582

ACRONYM: MH

MEDLINETA: Front Biosci

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