Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression.

Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Research Abstract Details 

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Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Abstract Text:

Hillary S Schaefer,Katherine M Putnam,Ruth M Benca,Richard J Davidson,

BACKGROUND: Relationships between aberrant social functioning and depression have been explored via behavioral, clinical, and survey methodologies, highlighting their importance in the etiology of depression. The neural underpinnings of these relationships, however, have not been explored. METHODS: Nine depressed participants and 14 never-depressed control subjects viewed emotional and neutral pictures at two functional magnetic resonance imaging (fMRI) scanning sessions approximately 22 weeks apart. In the interim, depressed patients received the antidepressant Venlafaxine. Positively rated images were parsed into three separate comparisons: social interaction, human faces, and sexual images; across scanning session, activation to these images was compared with other positively rated images. RESULTS: For each of the three social stimulus types (social interaction, faces, sexual images), a distinguishable circuitry was activated equally in non-depressed control subjects and post-treatment depressed subjects but showed a hypo-response in the depressed group pre-treatment. These structures include regions of prefrontal, temporal, and parietal cortices, insula, basal ganglia, and the hippocampus. CONCLUSIONS: The neural hypo-response to positively valenced social stimuli that is observed in depression remits as response to antidepressant medication occurs, suggesting a state-dependent deficiency in response to positive social incentives. These findings underscore the importance of addressing social dysfunction in research and treatment of depression.

Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Publishing Authors By Initials

HS Schaefer,KM Putnam,RM Benca,RJ Davidson,

For similar psychological phenomena and processes: mental processes: perception: visual perception research abstracts see: psychological phenomena and processes: mental processes: perception: visual perception research

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Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 60

Page Numbers: 974-86

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 14

MONTH: 06

YEAR: 2006

Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Keywords Mesh Terms:

KEYWORDS: Visual Perception

MESH TERMS: physiology

Chemical & Substance for Abstract: Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression.

AFFILIATION: Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin 53705-2280, USA.

Country: United States

AGENCY: United States NIMH

GRANT: R01-MH40747

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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