[Evaluation of the product specific standard input function for the IMP-ARG method]

[Evaluation of the product specific standard input function for the IMP-ARG method] Research Abstract Details 

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Tohru Shiga,Tomohito Kaji,Tomoya Kohno,Hiroyuki Kageyama,Chietsugu Katoh,Jun Hatazawa,Naohiko Oku,Isamu Narabayashi,Hitoya Ohta,Tsuyoshi Komori,Masuo Hayashi,Nagara Tamaki,Tohru Shiga,Tomohito Kaji,Tomoya Kohno,Hiroyuki Kageyama,Chietsugu Katoh,Jun Hatazawa,Naohiko Oku,Isamu Narabayashi,Hitoya Ohta,Tsuyoshi Komori,Masuo Hayashi,Nagara Tamaki,

To confirm the previous reports demonstrating the difference in the octanol extraction fractions between the currently available two N-isopropyl-4-iodoamphetamine (123I) products (IMP(A) and IMP(B)), we newly developed the standard input function for IMP(B) in 19 healthy volunteers and compared it with the established standard input function, which has been originally generated with IMP(A). The octanol extraction fractions of IMP(B) were stable from 5 minutes to 16 minutes post injection and significantly higher than those of IMP(A). The mCBFs calculated with IMP(B) by using the established standard input function for IMP(A) tended to be higher than those with the combination of IMP(A) and the established standard input function though the difference was not significant. When measured with IMP(B) combined with the correspondent standard input function, mCBFs were identical to those calculated with IMP(A) with the established standard input function, suggesting that the appropriate standard input function should be used according to the product used.

[Evaluation of the product specific standard input function for the IMP-ARG method] Publishing Authors By Initials

T Shiga,T Kaji,T Kohno,H Kageyama,C Katoh,J Hatazawa,N Oku,I Narabayashi,H Ohta,T Komori,M Hayashi,N Tamaki,T Shiga,T Kaji,T Kohno,H Kageyama,C Katoh,J Hatazawa,N Oku,I Narabayashi,H Ohta,T Komori,M Hayashi,N Tamaki,

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[Evaluation of the product specific standard input function for the IMP-ARG method] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Kaku igaku. The Japanese journal of nuclear medici

VOLUME: 44

Page Numbers: 1-7

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ISSN: 0022-7854

DAY: 4

MONTH: Feb

YEAR: 2007

[Evaluation of the product specific standard input function for the IMP-ARG method] Information

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LANGUAGE: jpn

NlmUniqueID: 2985202

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Grant and Affiliation Information for [Evaluation of the product specific standard input function for the IMP-ARG method]

AFFILIATION: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine.

Country: Japan

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MEDLINETA: Kaku Igaku

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