Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography.

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography. Abstract Text:

Joern J W Sandstede,Anne Roth,Wolfram Machann,Christine Kaupert,Dietbert Hahn,Joern J W Sandstede,Anne Roth,Wolfram Machann,Christine Kaupert,Dietbert Hahn,

To determine the risk of developing contrast induced nephropathy (CIN) in intermediate-risk patients receiving iodixanol, an iso-osmolar, dimeric non-ionic contrast agent, for CT in a clinical setting. Hundred consecutive patients referred for a contrast enhanced CT with a serum creatinine concentration>1.1mg/dl and/or a glomerular filtration rate (GFR)<90ml/min were included. Exclusion criteria were a serum creatinine>2.0mg/dl and a GFR<30ml/min or concurrent nephrotoxic agents. Between 60 and 140ml (mean 97+/-42ml) iodixanol (320mgI/ml) were administered at a flow of 2.5-3ml/s. Hydration with 500ml NaCl i.v. was performed before and after contrast injection. Follow-up was completed in 99 patients (age, 64+/-13 years, 68 men). CIN was defined as increase in serum creatinine concentration +0.5mg/dl or >25% above baseline within 72h after contrast administration. Serum creatinine concentration and GFR were 1.40+/-0.22, 1.29+/-0.29, and 1.26+/-0.29mg/dl and 52.2+/-13.9, 51.3+/-21.1, and 51.5+/-15.1ml/min on days 0, 3, and 7, respectively. Three out of 99 (3%) patients who received 90-110ml iodixanol revealed a CIN on day 3 without persistence on day 7. No specific therapy was needed. One out of 99 patients reported an exanthema on days 3 and 7. With the use of iodixanol in intermediate-risk patients, 3% of the patients develop CIN on day 3 without need for a specific therapy or persistence on day 7.

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography. Publishing Authors By Initials

JJ Sandstede,A Roth,W Machann,C Kaupert,D Hahn,JJ Sandstede,A Roth,W Machann,C Kaupert,D Hahn,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of radiology

VOLUME: 63

Page Numbers: 120-3

Journal Abbreviation:

ISSN: 0720-048X

DAY: 21

MONTH: 02

YEAR: 2007

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8106411

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography.

AFFILIATION: Department of Radiology, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany. sandstede@web.de

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Radiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography Related Publications

• A comparison of mouse and rabbit embryos for the production of transgenic animals by pronuclear microinjection.
• A pathophysiologic approach to the clinical management of arthritis and pain: current and future implications.
• Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins.
• Attempts to explain and reduce variability of superovulation.
• Behavioral effects of nicotine exposure from secondhand tobacco smoke among bar and restaurant workers.
• CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression.
• CMT1X phenotypes represent loss of GJB1 gene function.
• Comparative proteomic analysis of blue light signaling components in the Arabidopsis cryptochrome 1 mutant.
• Complete extirpation of benign breast lesions with an ultrasound-guided vacuum biopsy system.
• Duodenal mucosal protection by bicarbonate secretion and its mechanisms.
• Economy of mate attraction in the Cassin's finch.
• Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness.
• Evaluation of the nephrotoxicity of iodixanol in patients with predisposing factors to contrast medium induced nephropathy referred for contrast enhanced computed tomography.
• Fast mapping skills in the developing lexicon.
• Fate and effects of heavy metals in salt marsh sediments.
• Feasibility of estimating isokinetic knee torque using a neural network model.
• Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzees.
• Imaging spatiotemporal dynamics of Rac activation in vivo with FLAIR.
• Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
• Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy.
• Merocyanine dyes with improved photostability.
• NO-releasing aspirin exerts stronger growth inhibitory effect on Barrett's adenocarcinoma cells than traditional aspirin.
• Neural aspects of ghrelin-induced gastroprotection against mucosal injury induced by noxious agents.
• Non-compliance in surveillance for patients with previous resection of large (>= 1 cm) colorectal adenomas.
• Polarizability and Kerr constant of proteins by boundary element methods.
• Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer.
• Preparation of 14C-Spiro Ethers by Chamomile and their Use by an Investigation of Absorption.
• Primary lymphoma of the central nervous system: a clinical-pathological and immunohistochemical study of ten autopsy cases.
• Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging.
• Spatial location and its relevance for terminological inferences in bio-ontologies.