Evaluation of the mutagenic and genotoxic potential of ubiquinol.

Evaluation of the mutagenic and genotoxic potential of ubiquinol. Research Abstract Details 

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Evaluation of the mutagenic and genotoxic potential of ubiquinol. Abstract Text:

Mitsuaki Kitano,Fukutaro Mizuhashi,Hiroshi Kubo,Hideyuki Kishida,Kenji Fujii,Mikio Kitahara,Kazunori Hosoe,Mitsuaki Kitano,Fukutaro Mizuhashi,Hiroshi Kubo,Hideyuki Kishida,Kenji Fujii,Mikio Kitahara,Kazunori Hosoe,

Ubiquinol (the reduced form of coenzyme Q(10)) is the two-electron reduction product of ubiquinone (the oxidized form of coenzyme Q(10)), and has been shown to be an integral part of living cells, where it functions as an antioxidant in both mitochondria and lipid membranes. To provide information to enable a Generally Regarded as Safe (GRAS) evaluation for the use of ubiquinol in selected foods, a series of Organisation of Economic Cooperation and Development (OECD) and good laboratory practice (GLP) toxicological studies was conducted to evaluate the mutagenic and genotoxic potential of Kaneka QH brand of ubiquinol. Ubiquinol did not induce reverse mutations in Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 and Escherichia coli WP2uvrA at concentrations up to 5000 mu g/plate, in either the absence and presence of exogenous metabolic activation by rat liver S9. Likewise, ubiquinol did not induce chromosome aberrations in Chinese hamster lung fibroblast (CHL/IU) cells in short-term (6-h) tests with or without rat liver S9 at concentrations up to 5000 mu g/ml or in a continuous (24-h) treatment test at concentrations up to 1201 mu g/ml. Finally, no mortalities, no abnormal clinical signs, and no significant increase in chromosome damage were observed in an in vivo micronucleus test when administered orally at doses up to 2000 mg/kg/day. Thus, ubiquinol was evaluated as negative in the bacterial reverse mutation, chromosomal aberration, and rat bone marrow micronucleus tests under the conditions of these assays.

Evaluation of the mutagenic and genotoxic potential of ubiquinol. Publishing Authors By Initials

M Kitano,F Mizuhashi,H Kubo,H Kishida,K Fujii,M Kitahara,K Hosoe,M Kitano,F Mizuhashi,H Kubo,H Kishida,K Fujii,M Kitahara,K Hosoe,

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MEDLINE DATE: 2007 Nov-Dec

Evaluation of the mutagenic and genotoxic potential of ubiquinol. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of toxicology

VOLUME: 26

Page Numbers: 533-44

Journal Abbreviation: Int. J. Toxicol.

ISSN: 1091-5818

DAY: 10

MONTH: 12

YEAR: 2007

Evaluation of the mutagenic and genotoxic potential of ubiquinol. Information

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LANGUAGE: eng

NlmUniqueID: 9708436

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Grant and Affiliation Information for Evaluation of the mutagenic and genotoxic potential of ubiquinol.

AFFILIATION: Life Science Research Laboratories, Kaneka Corporation, Hyogo, Japan.

Country: United States

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MEDLINETA: Int J Toxicol

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