Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.

Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. Research Abstract Details 

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Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. Abstract Text:

Ning Li,Yan Song,Wenzhong Zhang,Wei Wang,Junshi Chen,Andrea W Wong,Ashley Roberts,Ning Li,Yan Song,Wenzhong Zhang,Wei Wang,Junshi Chen,Andrea W Wong,Ashley Roberts,

Magnolia bark extract (MBE) is an extract of the dried stem, root, or branch bark of magnolia trees that has been used historically in traditional Chinese and Japanese medicines, and more recently as a component of dietary supplements and cosmetic products. To study the genotoxic potential of MBE, a bacterial reverse mutation assay and an in vivo micronucleus test were conducted. Compositional analysis of the test substance revealed that MBE contains 94% magnolol and 1.5% honokiol. MBE exerted no mutagenic activity in various bacterial strains of Salmonella typhimurium and in Escherichia coli WP2 uvrA, either in the absence or presence of metabolic activation at all doses tested. In the micronucleus test, various doses of MBE did not affect the proportions of immature to total erythrocytes, nor did it increase the number of micronuclei in the immature erythrocytes of Swiss albino mice. The results of these studies demonstrate that MBE is not genotoxic under the conditions of the in vitro bacterial reverse mutation assay and the in vivo micronucleus test, and support the safety of MBE for dietary consumption.

Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. Publishing Authors By Initials

N Li,Y Song,W Zhang,W Wang,J Chen,AW Wong,A Roberts,N Li,Y Song,W Zhang,W Wang,J Chen,AW Wong,A Roberts,

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Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Regulatory toxicology and pharmacology : RTP

VOLUME: 49

Page Numbers: 154-9

Journal Abbreviation: Regul. Toxicol. Pharmacol.

ISSN: 0273-2300

DAY: 4

MONTH: 07

YEAR: 2007

Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. Information

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LANGUAGE: eng

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AFFILIATION: Department of Toxicological Safety Assessment, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China.

Country: United States

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MEDLINETA: Regul Toxicol Pharmacol

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