Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants.

Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants. Research Abstract Details 

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Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants. Abstract Text:

Sonia Borbone,Agnese Lupo,Maria Lina Mezzatesta,Floriana Campanile,Maria Santagati,Stefania Stefani,

This study was undertaken to test the in vitro activity of tigecycline against 117 clinically relevant Gram-positive pathogens and to correlate this activity with their resistance gene content. Overall, tigecycline showed a minimal inhibitory concentration (MIC) range of 0.015-0.5mg/L, able to inhibit potently all multiresistant streptococci, enterococci and MR staphylococci. Tigecycline was active against methicillin-resistant Staphylococcus aureus (MRSA) and enterococci, with MICs for 90% of the organisms (MIC(90)) of 0.25mg/L and 0.12mg/L, respectively, being more active than linezolid (MIC(90)=2mg/L) and quinupristin/dalfopristin (MIC(90)=0.5 and 2-4mg/L, respectively). Molecular characterisation of resistance determinants demonstrated the concomitant presence of different classes of genes: in particular, tet(M), erm(B) and erm(C) in Streptococcus agalactiae; tet(O), variably associated with different erm genes, in Streptococcus pyogenes; vanA, tet(M) and erm(B) in Enterococcus faecalis, and vanA and erm(B) in Enterococcus faecium. All the MRSA strains harboured SCCmec and erm genes and 50% possessed tet(K) with tet(M) genes. Staphylococcus epidermidis strains were only resistant to erythromycin. These results clearly demonstrate that tigecycline has a MIC(90) range of 0.015-0.5mg/L both against tetracycline-susceptible and -resistant isolates carrying other resistance determinants, suggesting that this drug could play an important role in the treatment of infections caused by these multiresistant Gram-positive pathogens.

Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants. Publishing Authors By Initials

S Borbone,A Lupo,ML Mezzatesta,F Campanile,M Santagati,S Stefani,

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Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of antimicrobial agents

VOLUME: 31

Page Numbers: 209-15

Journal Abbreviation: Int. J. Antimicrob. Agents

ISSN: 0924-8579

DAY: 23

MONTH: 07

YEAR: 2007

Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants.

AFFILIATION: Department of Microbiology, University of Catania, Via Androne 81, 95124 Catania, Italy.

Country: Netherlands

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MEDLINETA: Int J Antimicrob Agents

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