Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints.

Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints. Research Abstract Details 

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Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints. Abstract Text:

D P Arfsten,E R Wilfong,M Y-V Bekkedal,E W Johnson,S M McInturf,J S Eggers,D J Schaeffer,K R Still,

In 2002, the Naval Health Research Center Toxicology Detachment began a study to determine the effects of surgically implanted depleted uranium (DU) pellets on adult rat (e.g., P1 generation) health and reproduction. In this report, the effect of implanted DU on adult rat behavior and health is described. Adult Sprague-Dawley (SD) rats, 8 wk of age, were surgically implanted with 0, 4, 8, 12, or 20 DU pellets (1 x 2 mm); 20 DU pellets of size 1 x 2 mm approximates to 0.22 kg (0.5 lb) of DU in a 70-kg (154 lb) person. Control animals were implanted with 12 or 20 tantallum (Ta) pellets. The animals were then housed for up to 150 d postimplantation or 20% of an assumed 2-yr life span for rats. The concentration of uranium in urine directly correlated with the number of implanted DU pellets, indicating that DU was migrating into the body from the implanted pellets. Three male and 4 female animals died during the 150-d period of causes apparently not related to DU implantation. Behavioral testing found no definitive evidence of neurobehavioral perturbations associated with DU implantation. Uranium translocated to tissues known to sequester uranium (bone, teeth, and kidneys), but uranium concentrations varied considerably within each dose group and did not follow a dose-response pattern as anticipated. Serum chemistry values were within normal ranges for the SD rat. However, alanine aminotransferase measurements were significantly lower for rats implanted with 20 DU pellets as compared to sham surgery controls but not when compared to animals implanted with Ta pellets only. Phosphate measurements were significantly lower for female rats implanted with 20 DU pellets as compared to both sham surgery controls and animals implanted with Ta pellets only. Monocyte ratios were higher in adult rats implanted with 20 DU pellets as compared to sham surgery controls but not when compared to animals implanted with 20 Ta pellets. Mean platelet volume was found to be significantly lower for rats implanted with 20 DU pellets as compared to sham surgery controls but not when compared to animals implanted with 20 Ta pellets. Gross necropsy found no obvious tissue abnormalities in implanted rats, and the weights of major tissues did not differ between Ta- and DU-implanted animals. Histopathologic analysis of major tissues from animals implanted with 0 pellets, 20 Ta pellets, or 20 DU pellets found no differences between treatment groups. The findings of this study indicate that implantation of up to 20 DU pellets in adult rats did not have a significant negative impact on their general health and neurobehavioral capacities when assessed after 150 d of pellet implantation. However, the growing body of data on the potential health effects associated with DU exposure warrants further studies involving higher embedded DU body burdens in conjunction with longer surveillance periods postimplantation.

Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints. Publishing Authors By Initials

DP Arfsten,ER Wilfong,MY Bekkedal,EW Johnson,SM McInturf,JS Eggers,DJ Schaeffer,KR Still,

For similar inorganic chemicals: elements: actinoid series elements: uranium research abstracts see: inorganic chemicals: elements: actinoid series elements: uranium research

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Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of toxicology and environmental health. Pa

VOLUME: 70

Page Numbers: 1995-2010

Journal Abbreviation: J. Toxicol. Environ. Health Pa

ISSN: 1528-7394

DAY: 23

MONTH: Dec

YEAR: 2007

Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints. Information

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LANGUAGE: eng

NlmUniqueID: 100960995

Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints. Keywords Mesh Terms:

KEYWORDS: Uranium

MESH TERMS: urine

Chemical & Substance for Abstract: Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints. Information

Substance Name: Uranium

Registry Number: 7440-61-1

Grant and Affiliation Information for Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints.

AFFILIATION: Navy Drug Screening Laboratory, Naval Air Station, Jacksonville, Florida 32212-0113, USA. darryl.arfsten@med.navy.mil

Country: England

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MEDLINETA: J Toxicol Environ Health A

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