Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies.

Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies. Research Abstract Details 

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Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies. Abstract Text:

K Nakamura,A Ruiz-Juvera,A Kubo,S Hashimoto,

Monoclonal antibody against carcinoembryonic antigen (CEA) was labeled by the 111In-(Sn)-citrate technique and its characteristics were determined from the point of radioimmunotargeting studies. Antibodies of high specific radioactivity could be labeled with a high labeling yield of greater than 90% without any further purification step, and without loss of immunoreactivity. In biodistribution studies using nude mice bearing CEA-producing tumors, an extremely high tumor-to-blood ratio (40 on day 6) was obtained since 111In in the blood cleared very rapidly, but nonspecific 111In localized in the liver and spleen should be seriously considered.

Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies. Publishing Authors By Initials

K Nakamura,A Ruiz-Juvera,A Kubo,S Hashimoto,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of radiation applications an

VOLUME: 19

Page Numbers: 21-5

Journal Abbreviation:

ISSN: 0883-2897

DAY: 21

MONTH: Jan

YEAR: 1992

Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8611098

Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies. Information

Substance Name: stannous chloride

Registry Number: 7772-99-8

Grant and Affiliation Information for Evaluation of the 111In-(Sn)-citrate method to label antibodies for radioimmunotargeting studies.

AFFILIATION: Department of Radiology, School of Medicine, Keio University, Tokyo, Japan.

Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum B

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