Evaluation of peripheral and autonomic nerve function in Fabry disease.

Evaluation of peripheral and autonomic nerve function in Fabry disease. Research Abstract Details 

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Evaluation of peripheral and autonomic nerve function in Fabry disease. Abstract Text:

The neurological manifestations of Fabry disease include severe episodes of lancinating pain and burning paraesthesias in the extremities, often triggered by changes in temperature. The preferential involvement of small nerve fibres and the accumulation of storage product in the central autonomic nervous system and autonomic ganglia means that standard neurophysiological procedures cannot adequately evaluate the peripheral and autonomic nervous systems of affected patients. This paper describes the various methods that have been developed to assess impairment of temperature perception, vibratory perception, sudomotor and sweat gland function, and limb and superficial skin blood flow and vasoreactivity. These methods, including thermal provocation tests, quantitative sudomotor axon reflex testing and venous occlussion plethsmography, have been used effectively in patients with Fabry disease to measure the extent of neurological dysfunction. CONCLUSIONS: Effective methods for measuring neurological involvement in patients with Fabry disease have been developed. These methods will be valuable in assessing the response of patients to enzyme replacement therapy.

Evaluation of peripheral and autonomic nerve function in Fabry disease. Publishing Authors By Initials

For similar nervous system diseases: neuromuscular diseases: peripheral nervous system diseases research abstracts see: nervous system diseases: neuromuscular diseases: peripheral nervous system diseases research

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Evaluation of peripheral and autonomic nerve function in Fabry disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta paediatrica (Oslo, Norway : 1992). Supplement

VOLUME: 91

Page Numbers: 38-42

Journal Abbreviation: Acta Paediatr Suppl

ISSN: 0803-5326

DAY: 12

MONTH: 05

YEAR: 2002

Evaluation of peripheral and autonomic nerve function in Fabry disease. Information

Number of References: 29

LANGUAGE: eng

NlmUniqueID: 9315043

Evaluation of peripheral and autonomic nerve function in Fabry disease. Keywords Mesh Terms:

KEYWORDS: Peripheral Nervous System Diseases

MESH TERMS: physiopathology

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Grant and Affiliation Information for Evaluation of peripheral and autonomic nerve function in Fabry disease.

AFFILIATION: Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. max.hilz@neuro.imed.uni-erlangen.de

Country: Norway

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MEDLINETA: Acta Paediatr Suppl

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