Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow.

Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow. Abstract Text:

Maria Emília Santos Pereira Ramos,Bruno Coêlho Cavalcanti,Letícia Veras Costa Lotufo,Manoel Odorico de Moraes,Eneida de Moraes Marcílio Cerqueira,Cláudia Pessoa, Ramos, Cavalcanti, Lotufo,Manoel Odorico de Moraes, Cerqueira, Pessoa,

OBJECTIVE: The genotoxic potential of formocresol was assessed by comet assay on human peripheral blood lymphocytes and in vivo micronucleus in mice. STUDY DESIGN: Peripheral blood lymphocytes, obtained from healthy donors, were exposed directly with different dilutions of formocresol for 45 minutes at 37 degrees C. To verify the possibility of formocresol to induce DNA-protein cross-links, treated lymphocytes were incubated with proteinase K. Micronucleus test was performed on male Swiss mice treated with several dilutions of formocresol by single intraperitoneal injection. After treatment, bone marrow was sampled 24 and 48 hours after formocresol administration. RESULTS: Formocresol did not produce detectable DNA damage as evaluated by comet assay. However, after proteinase K exposure, a dose-dependent increase of DNA migration was observed. Formocresol induced a significant increase in micronucleus frequencies at the highest dilution only at 24 hours after administration. CONCLUSION: Formocresol induced DNA-protein cross-links and an increased frequency of micronucleus.

Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow. Publishing Authors By Initials

ME Ramos,BC Cavalcanti,LV Lotufo,MO de Moraes,Ede Cerqueira,C Pessoa,ME Ramos,BC Cavalcanti,LV Lotufo,MO de Moraes,Ede Cerqueira,C Pessoa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oral surgery, oral medicine, oral pathology, oral

VOLUME: 105

Page Numbers: 398-404

Journal Abbreviation:

ISSN: 1528-395X

DAY: 18

MONTH: Mar

YEAR: 2008

Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9508562

Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow.

AFFILIATION: Department of Health, Feira de Santana State University, Feira de Santana, Brazil.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Oral Surg Oral Med Oral Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow Related Publications

• Adverse reactions of fluorescein angiography: a prospective study.
• Affective learning enhances visual detection and responses in primary visual cortex.
• Affective learning increases sensitivity to graded emotional faces.
• Affective learning modulates spatial competition during low-load attentional conditions.
• Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells.
• Behavioural evidence of sex-linked colour vision polymorphism in the squirrel monkey Saimiri ustus.
• Color vision in the black howler monkey ( Alouatta caraya).
• Cytotoxicity and genotoxicity of ingenamine G isolated from the Brazilian marine sponge Pachychalina alcaloidifera.
• Evaluation of mutagenic effects of formocresol: detection of DNA-protein cross-links and micronucleus in mouse bone marrow.
• Fear perception: can objective and subjective awareness measures be dissociated?
• NMR spectral assignments of a new [C--O--C] isoflavone dimer from Andira surinamensis.
• Nematicidal and larvicidal activities of the essential oils from aerial parts of Pectis oligocephala and Pectis apodocephala Baker.
• Not Available
• On the relationship between emotion and cognition.
• Perceptual filling-in of stereoscopically presented targets.
• Perceptual visual filling-in of toxoplasmic retinochoroiditis scotomas.
• Phase diagrams of a CTAB/organic solvent/buffer system applied to extraction of enzymes by reverse micelles.
• Protein partitioning in poly(ethylene glycol)/sodium polyacrylate aqueous two-phase systems.
• Removal of proteases from Clostridium perfringens fermented broth by aqueous two-phase systems (PEG/citrate).
• Sustained and transient modulation of performance induced by emotional picture viewing.
• [Clinical experience with a new antispasmodic-analgesic combination (preliminary note)]
• [Clinico-therapeutic trial of a new amebicide.]
• [Emotional stimuli: sensory processing and motor responses]
• [Low prevalence of dyschromatopsia using the fourth edition of HRR (Hardy, Rand and Rittler) pseudoisochromatic plate test among the Indian population of Lalima village, Terena]
• [Not Available.]
• [Not Available.]
• [Samuel Barnsley Pessôa: bio-bibliographical data.]
• [Schistosomiasis mansoni. Epidemiology.]
• [THE USE OF AN ANORETIC SUBSTANCE IN OBESE DIABETICS.]
• [Trypanosoma hogei n. sp., parasite of the false cobra(Rachidelus brazili Boul.)]