Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells.

Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells. Research Abstract Details 

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Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells. Abstract Text:

Emma Caraher,Jonathan Collins,Gillian Herbert,Philip G Murphy,Charles G Gallagher,Mary J Crowe, Callaghan, McClean,

Pandoraea species are emerging opportunistic pathogens capable of causing chronic lung infections in cystic fibrosis patients. This study examined the interactions of 17 Pandoraea isolates from the five identified species (Pandoraea apista, Pandoraea norimbergensis, Pandoraea pulmonicula, Pandoraea sputorum and Pandoraea pnomenusa) plus two Pandoraea genomospecies isolates with lung epithelial cells and their ability to form biofilms in vitro. Only three isolates showed an ability to invade A549 lung epithelial cells, and only one isolate was able to form biofilms. In contrast, all isolates triggered a pronounced pro-inflammatory response, with elevation of both interleukin (IL)-6 (two- to 19-fold) and IL-8 (10- to 50-fold) above that observed for a control strain of Escherichia coli. This property is likely to be a major factor in the pathogenesis of the genus.

Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells. Publishing Authors By Initials

E Caraher,J Collins,G Herbert,PG Murphy,CG Gallagher,MJ Crowe,M Callaghan,S McClean,

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Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medical microbiology

VOLUME: 57

Page Numbers: 15-20

Journal Abbreviation: J. Med. Microbiol.

ISSN: 0022-2615

DAY: 10

MONTH: Jan

YEAR: 2008

Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells.

AFFILIATION: 1Department of Applied Science and National Institute of Cellular Biotechnology, Institute of Technology, Tallaght, Dublin 24, Ireland.

Country: England

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MEDLINETA: J Med Microbiol

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