Evaluation of Colposcopically Directed Cervical Biopsies Yielding a Histologic Diagnosis of CIN 1,2.

Evaluation of Colposcopically Directed Cervical Biopsies Yielding a Histologic Diagnosis of CIN 1,2. Research Abstract Details 

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Evaluation of Colposcopically Directed Cervical Biopsies Yielding a Histologic Diagnosis of CIN 1,2. Abstract Text:

Christine Molloy,Charles Dunton,Pamela Edmonds,Mary F Cunnane,Thomas Jenkins,

OBJECTIVE.: To determine the prognostic value of the diagnostic category CIN 1,2. MATERIALS AND METHODS.: Computerized pathology records of patients with CIN 1,2 at colposcopically directed biopsy followed by treatment with excision were examined, and we compared the diagnostic biopsy with the final tissue diagnosis. Two pathologists who were blinded to the final diagnosis reviewed the original biopsies independently. The ability of the referee pathologist to predict CIN 2 or 3 lesions and interobserver consistency are described. RESULTS.: Sixty-nine cases of biopsies with CIN 1,2 were reviewed. Nineteen of these patients were lost to follow-up. Of the 46 cases with either an excisional biopsy or hysterectomy, 12 cases (26.1%) demonstrated CIN 2 or greater. Pathologist A and B correctly predicted the high-grade lesions in 66.7% and 58.3% of cases reviewed. Pathologist A and B agreed with each other in 33 of the 46 cases (71.1%). CONCLUSIONS.: 1) CIN 1,2 on a colposcopic biopsy is associated with a high-grade lesion in 26.1% of the cases. 2) Experienced gynecologic pathologists can identify these high-grade lesions on review in only two thirds of the cases. 3) CIN 1,2 is a useful diagnostic category to prevent undertreatment.

Evaluation of Colposcopically Directed Cervical Biopsies Yielding a Histologic Diagnosis of CIN 1,2. Publishing Authors By Initials

C Molloy,C Dunton,P Edmonds,MF Cunnane,T Jenkins,

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Evaluation of Colposcopically Directed Cervical Biopsies Yielding a Histologic Diagnosis of CIN 1,2. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of lower genital tract disease

VOLUME: 6

Page Numbers: 80-3

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ISSN: 1089-2591

DAY: 19

MONTH: Apr

YEAR: 2002

Evaluation of Colposcopically Directed Cervical Biopsies Yielding a Histologic Diagnosis of CIN 1,2. Information

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LANGUAGE: eng

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AFFILIATION: 1 Departments of Obstetrics and Gynecology and 2 Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Country: United States

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MEDLINETA: J Low Genit Tract Dis

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